2022 CAP Congress / Congrès de l'ACP 2022

Session

T2 -1 Advances in Physics in Biology and Medicine Symp.: Protein design and diffusion (DPMB) | Symposium sur les progrès en physique dans la biologie et la médecine: conception de protéines et diffusion (DPMB)

T2-1

7 Jun 2022, 10:45

McMaster University

Conveners

T2 -1 Advances in Physics in Biology and Medicine Symp.: Protein design and diffusion (DPMB) | Symposium sur les progrès en physique dans la biologie et la médecine: conception de protéines et diffusion (DPMB)

• Ozzy Mermut

3442. (I) Fast and precise: How transcription factors find their targets

Cecile Fradin (Dept. of Physics and Astronomy, McMaster University)

07/06/2022, 10:45

Symposia Day (DPMB) - Advances in Biological and Medical Physics Symposium

Invited Speaker / Conférencier(ère) invité(e)

Protein diffusion plays a ubiquitous role in molecular signalling pathways. As our understanding of the organization and compartmentalization of the cellular environment progresses, we start to better appreciate the complexity of the diffusive transport of proteins, and the control this transport may exert in signalling. One striking example of a diffusion-controlled process is the search of...

3395. Probing the Stochastic Properties of DNA Driven by Topology-relaxing Enzyme Activity

Dr Maria Kilfoil (University of Prince Edward Island, Dept of Physics)

07/06/2022, 11:15

Physics in Medicine and Biology / Physique en médecine et en biologie (DPMB-DPMB)

Oral (Non-Student) / Orale (non-étudiant(e))

DNA topology-relaxing enzymes in the cell nucleus produce simplified topology, allowing entangled duplex DNA strands to pass one through another, essential for many critical cell nuclear processes including successful DNA segregation during cell division. Here, we carry out 1-point and 2-point microrheology on a model system of DNA at physiologically-relevant concentrations with and without...

3186. The lawnmower: an artificial protein-based burnt-bridge molecular motor

Chapin Korosec (York University)

07/06/2022, 11:30

Physics in Medicine and Biology / Physique en médecine et en biologie (DPMB-DPMB)

Oral (Non-Student) / Orale (non-étudiant(e))

Molecular motors are essential for powering directional motion at the cellular level, including transport and sorting of cargo, cell locomotion and division, and remodelling of the extracellular environment. Such molecular motors are made out of proteins whose directed motion is coupled to the consumption of chemical free energy. Inspired by such biological machines, significant strides have...

3020. (G*) Protein folding and fold switching of the C-terminal domain of transcription factor RfaH.

Bahman Seifi

07/06/2022, 11:45

Symposia Day (DPMB) - Advances in Biological and Medical Physics Symposium

Oral Competition (Graduate Student) / Compétition orale (Étudiant(e) du 2e ou 3e cycle)

The classical view holds that proteins fold into a three-dimensional structure or native state, which determines the biological function of the protein. According to the energy landscape theory, folding proceeds on a rough funnel-shaped multidimensional free energy surface to the native conformation. However, some proteins have recently been discovered to reversibly switch between two entirely...

3390. (G*) Tracking Diffusion and Oligomerization of M2 Receptors in Live Cells

Xiaohan Zhou

07/06/2022, 12:00

Symposia Day (DPMB) - Advances in Biological and Medical Physics Symposium

Oral Competition (Graduate Student) / Compétition orale (Étudiant(e) du 2e ou 3e cycle)

Important insights about the signaling mechanisms of G Protein Coupled Receptors (GPCRs) can be learned from their supramolecular assembly. Recent studies in our lab have shown that the M2 muscarinic receptor (M2R), as well as its cognate G protein (Gi), can be purified as oligomers, yet the size and the dynamics of these oligomers, as well as their function are not fully understood in vivo....