Siam Physics Congress 2018

Control Theory for HIV Dynamics: Sliding Mode Control in Antiviral Drug Therapy

21 May 2018, 13:45

15m

Phitchit Room

Oral Biological Physics and Biomedical Engineering A1: Biological

Speaker

Mr Weera Yukunthorn (Kanchanaburi Rajabhat University)

Description

We study the dynamics of human immunodeficiency virus (HIV) infection under HIV antiviral drug therapy. In sense of control theory, the drug efficiency is treated as an controller. In this paper, we reduce the nonlinear terms and reconstruct problem as mathematical model in control system. The sliding mode control (SMC) is applied to control contact rate between CD4+ T lymphocyte (CD4+ T-cell) and HIV. A switching controller is investigated to establish asymptotically stability of the sliding surface as desired. Finally we illustrate simulation results of CD4+ T-cells, infected T-cells, Viral load and control action.

Presentation materials

SPC2018.pdf

Peer reviewing

Paper

Accepted on 11 Sept 2018 by spc2018 narasuan

Paper files:

• revision3.zip