2022 CAP Congress / Congrès de l'ACP 2022

Session

W2-3 Biophysics Outside the Box (DPMB) | Biophysique hors de la boîte (DPMB)

W2-3

8 Jun 2022, 13:15

McMaster University

Conveners

W2-3 Biophysics Outside the Box (DPMB) | Biophysique hors de la boîte (DPMB)

• Melanie Campbell

3148. (I) Functional and Functionalized Membranes

Maikel Rheinstadter

08/06/2022, 13:15

Physics in Medicine and Biology / Physique en médecine et en biologie (DPMB-DPMB)

Invited Speaker / Conférencier(ère) invité(e)

Cell membranes are complex dynamic structures, and their composition and structure are major determinants of pathology. It is now commonly accepted that the membranes’ physical properties, such as fluidity and thickness, are determining factors for permeability, partitioning of drug molecules, and protein aggregation. Membrane-interacting molecules can in some instances be expected to have a...

3239. (G) Diversity-generating host-disease coevolution with CRISPR adaptive immunity

Madeleine Bonsma-Fisher

08/06/2022, 13:45

Physics in Medicine and Biology / Physique en médecine et en biologie (DPMB-DPMB)

Oral not-in-competition (Graduate Student) / Orale non-compétitive (Étudiant(e) du 2e ou 3e cycle)

Bacteria are under constant threat from viruses, and some bacteria possess adaptive immune systems that provide protection through a genomic 'memory' of past viral infections. In conjunction with viral evolution, this creates a diverse population of bacteria where each cell has a unique viral genomic imprint. The fate of the bacterial population depends on the rate at which memories are...

3030. (G*) The role of ammonium ions in prebiotic RNA polymerization in hot-cold and hydration-dehydration cycles

Alix Dujardin

08/06/2022, 14:00

Physics in Medicine and Biology / Physique en médecine et en biologie (DPMB-DPMB)

Oral Competition (Graduate Student) / Compétition orale (Étudiant(e) du 2e ou 3e cycle)

The RNA world proposed by Gilbert in 1986 envisions that the first genetic polymers that formed on the early pre-biotic Earth were based on RNA polymerization and replication. Ever since, researchers have tried to synthesize RNA without enzymes by using catalysts such as clay, lipids, and inorganic salts. We investigated the formation of RNA by using hot-cold and hydration-dehydration cycles...

3296. (G*) The roles of secondary metabolite production in sustaining microbial diversity

Mr Ga Ching Lui (University of Toronto)

08/06/2022, 14:15

Physics in Medicine and Biology / Physique en médecine et en biologie (DPMB-DPMB)

Oral Competition (Graduate Student) / Compétition orale (Étudiant(e) du 2e ou 3e cycle)

High diversity at steady state is theoretically difficult to be attained in well-mixed systems, in which there are only a small number of growth-limiting factors. Broadly speaking, it is related to degrees of freedom present in the system. To account for the rich diversity observed in nature, various mechanisms such as fluctuation and spatial heterogeneity have been proposed. A typical way...

3238. (G*) Using Phytoglycogen as an Agent to Improve the Water Solubility of Bioactive Compounds

Nicholas van Heijst

08/06/2022, 14:30

Physics in Medicine and Biology / Physique en médecine et en biologie (DPMB-DPMB)

Oral Competition (Graduate Student) / Compétition orale (Étudiant(e) du 2e ou 3e cycle)

Phytoglycogen (PG) is a compact, dendrimeric and naturally occurring polysaccharide produced in the kernels in sweet corn. PG is soft, porous, bioavailable and nontoxic which makes it ideally suited for applications in human health and nutrition. In the pharmaceutical field, many newly-introduced drugs suffer from poor water solubility and the enhancement of their bioavailability is a major...