In current particle radiotherapy practice it is necessary to evaluate the radiation dosimetry and monitor the beam delivery procedures ideally using a simplified compact instrument with detailed time, spatial and directional response. For this purpose, we developed a non-invasive technique for wide field-of-view tracking and high-resolution dose monitoring of delivered particle accelerator...
Small-angle X-ray scattering (SAXS), often referred to as dark-field signal, provides information about the microstructure of non-crystalline samples at sub-ฮผm scales, unresolvable by conventional methods like micro-CT [1]. The directionality of the dark field can be exploited to extract the main orientations of microstructural features within the sample. Dark-field imaging enables the...
Boron Neutron Capture Therapy (BNCT) is an innovative and highly selective treatment against cancer. Nowadays in-vivo dose measurements and monitoring are important issues to carry out such therapy in clinical environments. In this work, different imaging methods were tested for dosimetry and tumor monitoring in BNCT based on a Compton camera detector. A dedicated data-set was generated...
Hadron therapy (HT) ensures extremely accurate dose conformity around tumor targets, reducing doses in adjacent healthy tissues and thereby providing enhanced safeguarding for at-risk organs. Heavier ions such as $^{4}\text{He}$, $^{12}\text{C}$, or $^{16}\text{O}$ could be more effective than protons due to their higher energy deposited per unit of track length (Linear Energy Transfer, LET)...
The MONOLITH H2020 ERC Advanced project aims at producing a high-granularity monolithic silicon pixel detector with picosecond-level time stamping. To obtain such extreme timing the project exploits: i) a fast and low-noise SiGe BiCMOS electronics; ii) a novel sensor concept, the Picosecond Avalanche Detector (PicoAD), that uses a patented multi-PN junction to engineer the electric field and...
Position sensitive detectors for radiation imaging have shown as very valuable technologies to further reduce the radioactive background in the very large, current and future, detectors designed to discover the signals of dark matter interaction or neutrinoless double beta decay. I will overview the activities at the Canfranc Underground Lab, with focus on recent developments in low background...
(Single-layer) particle tracking with Timepix3 for radiation field characterization and interaction point reconstruction within MoEDAL during PbPb collisions in 2018
The MoEDAL collaboration
MoEDAL-MAPP [1,2] is an LHC experiment dedicated to search for physics beyond the standard model through detection of exotic particles, amongst others magnetic monopoles (MM) or highly...
Abstract
X-ray Virtual Histology (XVH) has been proposed as a tool for improving the workflow of histopathological evaluation. Compared to conventional histology, which is inherently a bi-dimensional technique, XVH is based on micro-computed tomography (ยตCT), thus providing a 3D depiction of the imaged sample. This feature proved to be beneficial in the identification of...
In this work, a method for enhanced detection and imaging of the radiation field generated in pencil beam scanning (PBS) proton therapy delivered at conventional and ultra-high-dose rates (UHDR) is presented. This work specifically aims to quantify the dose, flux and linear energy-transfer spectra (LET) of the stray radiation measured outside the target volume including contribution from...
Silicon Carbide (SiC) detectors are recently emerging as promising alternative detectors for many applications in radiation detection, including dosimetry for radiotherapy, thanks to the observed high radiation hardness, time and energy resolution and the very good signal to noise ratio. SiC is, indeed, a semiconductor composed by 50% of silicon and 50% of carbon characterized by a wide...
Members of the Timepix family of detectors [1], [2] have been successfully used
as single-layer particle identification devices in space dosimetry. The advantage
of this approach over standard absorbed dose measurements is that it enables a
more accurate estimate of biological dose because in addition to absorbed dose,
the composition of the radiation field can be analyzed simultaneously....
C. Bฤlan1,2 *, C. Oancea3, G. Mytsin4, S. Shvidky4, A. Molokanov4, V. Chiศ1, C. Granja3
1. Faculty of Physics, Babeศ-Bolyai University, Cluj-Napoca, Romania
2. Radiotherapy Department, The Oncology Institute โProf. Dr. Ion Chiricutaโ, Cluj-Napoca, Romania
3. ADVACAM, Prague, Czech Republic
4. Joint Institute for Nuclear Research (JINR), Dzhelepov Laboratory of Nuclear Problems, Dubna
*...
Ion beam therapy effectively treats radiation-resistant and deeply located tumors but requires meticulous planning due to wide safety margins imposed by current technology. Proton transmission imaging, using protons instead of x-rays for image acquisition, is pivotal for precise treatment planning by directly probing the proton stopping power, reducing uncertainties, and enabling real-time...
X-and ฮณ-rays are a unique window into the most extreme environments in the Universe such as accretion discs around neutron stars or black holes. The measurement of the polarization of the detected photons adds parameter space further allowing for advancing our current understanding of astrophysical ฮณ-ray sources and environmental conditions by probing physical anisotropies, for example...
X-ray spectral imaging exploits the distinct energy dependence of the attenuation properties of different materials to produce quantitative maps of the chemical components inside a sample. In this context, the continuous development of new energy-sensitive detectors has led to a growing interest in X-ray spectral imaging, thereby enlarging the field of applications. The devices suitable for...
This work focuses on optimizing the properties of photon counting imaging detectors of Timepix family with Silicon, CdTe and GaAs sensors.
The optimization addresses two distinct goals:
a) Achieving the best energy resolution for specific target applications such as X-ray diffraction, X-ray fluorescence imaging or absorption K-edge imaging. The energy resolution of 130 eV (Gaussian fit...
Ion-beam therapy has the great potential to improve cancer treatments compared to the standard radiotherapy based on photons. This is due to the fact that ion beams can provide dose distributions that are strongly focused on the tumor volume.
However, in clinical practice this potential is often not fully exploited, because the highly-focused dose distribution has an increased sensitive to...
Resonant Inelastic X-ray Scattering (RIXS) is a powerful spectroscopic technique that can probe complex electronic-structural information. Due to the wealth of possible science cases (ranging from quantum-correlated materials to photochemistry and catalysis), RIXS spectrometers have become integral parts of the scientific landscape at most synchrotron facilities and X-ray Free Electron Lasers...
Spectral and phase contrast X-ray imaging techniques have recently emerged as fundamental tools for the improvement of image quality. X-ray spectral imaging (XSI) involves the acquisition of X-ray images at multiple energies, exploiting the energy-dependent nature of X-ray attenuation to provide material composition information. This technique offers an optimal solution for visualizing and...
