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Dr Sergio Cruz-Leon (Max Planck Institute of Biophysics)03/03/2026, 11:00
High-confidence 3D template matching (hcTM) turns in situ cryoET tomograms into simulation-ready subcellular segments. Multiscale simulations then make predictions later confirmed experimentally. For example, how mutations or composition changes propagate to mesoscale organization and biological function. Examples include human chromatin organization, viral transport and mutation-driven...
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Prof. Lukas Stelzl (Johannes Gutenberg University Mainz & IMB)03/03/2026, 11:20
Cellular processes are organized by the phase separation of proteins into biomolecular condensates. These condensates are regulated by post-translational modifications, most notably phosphorylation. Phosphorylation of proteins is catalysed by kinases which consumes the chemical fuel ATP. While the phosphorylation of TDP-43 is closely linked to neurodegenerative disease, how TDP-43 is...
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Dr Karen Palacio-Rodriguez (Max Planck Institute of Biophysics)03/03/2026, 16:00
During mitotic exit, the nuclear envelope seals spindle‑microtubule holes in a process mediated via LEM2‑ESCRT. Cryo-electron tomography (Cryo-ET) shows LEM2-ESCRT filament architecture but not the sealing mechanism. We built a digital twin by integrating Cryo‑ET with multiscale molecular dynamics simulations of filaments in a 90 nm membrane hole, capturing conformational changes, showing how...
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Dr Soumaya Zaghbani (Max Planck Institute of Biophysics)03/03/2026, 16:20
Correlative light and electron microscopy (CLEM) links dynamic functional imaging with ultrastructural detail, yet automated correlation remains unresolved due to the difficulty of bridging two fundamentally different microscopy modalities. Current approaches either bypass segmentation or rely on generic models, leading to poor or inconsistent alignment. We present Deep-SegCLEM, a fully...
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Ms Mara Müller (MPI for Brain Research)04/03/2026, 09:45
When stressed, all cells downregulate protein synthesis, to conserve energy and shift resources towards repair. Here, we show that in some mammalian cells, including neurons, stress also results in the formation of inactive ribosome-ribosome clusters (disomes). Using cryogenic electron tomography we visualized ribosomes in situ and observed that this dimerization is mediated by a homotypic...
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Mr Jonas Elpelt (FIAS)04/03/2026, 10:05
We study time-irreversibility in spontaneous neural activity as a multiscale dynamical phenomenon. Using large-scale Neuropixels recordings across mouse brain areas, we quantify temporal asymmetry from milliseconds to seconds (30–0.5 Hz) with complementary computational measures capturing population-level asymmetry, metastable state fluxes, and state-space divergence. This framework enables...
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Prof. Alexander Gottschalk (Goethe University)04/03/2026, 11:45
Gap junctions (GJs) are intercellular channels that mediate electrical signals and transfer of small molecules. They are crucial for brain, heart, and other organ functions. While molecular structures of purified homomeric GJs are available, information of in situ structures is lacking. In vivo, GJs can form heteromers with different functionalities and may associate with other proteins. Here,...
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Dr Veronika Thallmair (Philipps University Marburg)04/03/2026, 12:05
Membrane contact sites between the ER and the PM are site of non-vesicular lipid transport as they harbor various lipid transfer proteins. They are established by protein tethers among which Extended Synaptotagmins (E-Syts) are the most abundant family in mammals. E-Syts are ER-resident and regulate ER-PM connectivity via reversible association of their C2 domains with lipids at the PM. Here,...
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Dr Tim Liebisch (EMBL Barcelona)04/03/2026, 16:00
Limb development is regulated by feedback between the tissue-scale mechanics and cellular decisions–migration, contraction, division, and death–implemented through gene-regulatory networks. The dynamically changing states of these cellular networks reflect the decisions being made. To integrate these interactions across 3 scales: genes, cells, and tissues, we develop a 3D cell-based model in...
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Prof. Liangyi Chen (National Biomedical Imaging Center, Peking University)04/03/2026, 16:20
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Dr Ramachandra M. Bhaskara (Goethe University)04/03/2026, 17:30
FAM134B drives selective ER-phagy to maintain ER homeostasis. Modeling, coarse-grained MD, and experiments capture RHD-driven curvature induction/sensing (isoform-specific), ubiquitination-triggered clustering, and IDR-amplified ER budding. These self-organizing principles inform a hierarchical digital twin of the ER–phagophore contact site linking membrane mechanics/curvature, FAM134B–LC3B...
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Prof. Birgit Strodel (FZ Jülich)04/03/2026, 17:50
This work explores digital twins for innate immunity, focusing on human guanylate-binding protein 1 (hGBP1) and its role in targeting intracellular pathogens. Using coarse-grained molecular dynamics simulations, we examine protein-membrane interfaces with realistic pathogen membranes. We find that hGBP1 interacts with various membrane types; negatively charged lipids enhance affinity, while...
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Dr Josep BIayna (Goethe University)05/03/2026, 11:00
Intron retention (IR) is an important regulator of RNA fate, yet its spatial and temporal organization in human cells remains poorly understood. Here, we investigate the dynamics, localization, and regulation of intron-retained RNAs in pluripotent stem cells using compartment-resolved transcriptional shutdown, sequence-based modeling, and advanced RNA imaging. We focus on the relationship...
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Prof. Stefanie Kaiser (Goethe University)05/03/2026, 11:20
Digital twins in structural cell biology critically depend on experimental data quality and interpretability. RNA is a central molecular layer, yet its mass spectrometric analysis remains analytically fragile. I will discuss why RNA-MS cannot be treated as an extension of proteomics and how intrinsic ambiguity, redundancy, and modification complexity challenge confidence. I argue that explicit...
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Dr Fabio Lolicato (Heidelberg University)05/03/2026, 14:00
Fibroblast Growth Factor 2 (FGF2) is a key cell survival factor involved in tumor-induced angiogenesis. Unlike most secreted proteins, FGF2 lacks a signal peptide and is exported via unconventional protein secretion (UPS), bypassing the ER/Golgi. It translocates directly across the plasma membrane (Type I UPS), a process initiated by PI(4,5)P₂- mediated recruitment to the inner leaflet....
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Mr Lars Dingeldein (FIAS)05/03/2026, 14:20
Biomolecules are inherently flexible, continuously transitioning between conformations to carry out their cellular functions. Cryo–electron microscopy (cryo-EM) enables us to image individual biomolecules at near-atomic resolution. As a result, an image dataset can capture the entire biomolecular ensemble at once. By comparing cryo-EM images to structural hypotheses, one can identify the...
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Ms Srilakshmi Kalathil (Goethe University)05/03/2026, 16:00
he p53 family member p63 exhibits multiple isoforms and functional domains, with ΔNp63α serving as a critical transcriptional regulator implicated in epithelial-mesenchymal transition. While the various domains of ΔNp63α have been extensively characterized, the precise function of its Sterile Alpha Motif (SAM) domain stays elusive. Mutations within the SAM domain are associated with...
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Mr Thilo Duve (FIAS)05/03/2026, 16:20
Molecular photoswitches are light-responsive compounds that undergo reversible conformational changes upon irradiation. We present Martini 3 coarse-grained models for seven photoswitches, parameterized using semi-empirical reference data and experimental water–octanol partitioning. These models enable the development of digital twins for light-controlled biological systems including membrane...
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