Name: Giersch International Conference & SCALE Kick-Off
Start: 2026-03-02T09:00:00+01:00
End: 2026-03-05T19:15:00+01:00
Location: FIAS / OSZ

Giersch International Conference & SCALE Kick-Off

from Monday, March 2, 2026 (9:00 AM) to Thursday, March 5, 2026 (7:15 PM)

Monday, March 2, 2026

4:00 PM Welcome: Registration and Coffee
Registration and Coffee
4:00 PM - 5:00 PM
Room: Lecture Hall

5:00 PM Welcome: Opening Remarks
Opening Remarks
5:00 PM - 5:20 PM
Room: Lecture Hall
5:20 PM Invited Talks
5:20 PM - 6:50 PM
Room: Lecture Hall
Contributions

5:20 PM Toward Digital Twins of Development and Disease - Dagmar Iber (ETH Zürich)

6:05 PM Integrative Structural Biology in the era of Artificial Intelligence - Max Bonomi (Institut Pasteur)
7:00 PM Welcome: Reception
Reception
7:00 PM - 8:30 PM
Room: Faculty Club
Tuesday, March 3, 2026
9:00 AM Invited Talks
9:00 AM - 10:30 AM
Room: Lecture Hall
Contributions

9:00 AM How cellular architecture modulates drug response - Stefan Knapp (Goethe University)

9:45 AM Bayesian metamodeling of early T-cell antigen receptor signaling accounts for its nanoscale activation patterns - Barak Raveh (The Hebrew University of Jerusalem)
10:30 AM Coffee Break
Coffee Break
10:30 AM - 11:00 AM
Room: Lecture Hall
11:00 AM Short Talk
11:00 AM - 11:45 AM
Room: Lecture Hall
Contributions

11:00 AM From in situ cryoET to digital twins of subcellular segments - Sergio Cruz-Leon (Max Planck Institute of Biophysics)

11:20 AM Control of the condensation of TDP-43 by enzymatic phosphorylation: a perspective from molecular dynamics simulations - Lukas Stelzl (Johannes Gutenberg University Mainz & IMB)
11:45 AM Invited Talks
11:45 AM - 12:30 PM
Room: Lecture Hall
Contributions

11:45 AM Computational tools for building models of entire biological systems from light and electron microscopy - Stephan Preibisch (HHMI Janelia)
12:30 PM LUNCH BREAK
LUNCH BREAK
12:30 PM - 2:00 PM
2:00 PM Invited Talks
2:00 PM - 3:30 PM
Room: Lecture Hall
Contributions

2:00 PM From integrative structural biology to cell biology - Andrej Sali (UCSF)

2:45 PM Biomolecular condensate architecture of an autophagic cargo at molecular resolution in situ - Florian Wilfing (Max Planck Institute of Biophysics)
3:30 PM Coffee Break
Coffee Break
3:30 PM - 4:00 PM
Room: Lecture Hall
4:00 PM Short Talk
4:00 PM - 4:45 PM
Room: Lecture Hall
Contributions

4:00 PM Multiscale Modeling of Nuclear Membrane Sealing - Karen Palacio-Rodriguez (Max Planck Institute of Biophysics)

4:20 PM Deep-SegCLEM: unified segmentation and matching for correlative light–electron microscopy - Soumaya Zaghbani (Max Planck Institute of Biophysics)
4:45 PM Invited Talks
4:45 PM - 6:15 PM
Room: Lecture Hall
Contributions

4:45 PM Towards Digital Twins of Nuclear Pores - Martin Beck (Max Planck Institute of Biophysics)
6:15 PM POSTER SESSION

6:15 PM - 7:45 PM
Room: Room 0.101 (next to lecture hall)
Wednesday, March 4, 2026
9:00 AM Invited Talks
9:00 AM - 9:45 AM
Room: Lecture Hall
Contributions

9:00 AM Using digital twins to probe the origins of intelligence - Samantha Wood (Indiana University Bloomington)
9:45 AM Short Talk
9:45 AM - 10:30 AM
Room: Lecture Hall
Contributions

9:45 AM rRNA expansion segments mediate the oligomerization of inactive animal ribosomes - Mara Müller (MPI for Brain Research)

10:05 AM Area-specific signatures of time-irreversibility in spontaneous neural activity of the mouse brain - Jonas Elpelt (FIAS)
10:30 AM Coffee Break
Coffee Break
10:30 AM - 11:00 AM
Room: Lecture Hall
11:00 AM Invited Talks
11:00 AM - 11:45 AM
Room: Lecture Hall
Contributions

11:00 AM Towards Digital Twins of the cerebral cortex - Sasha van Albada (FZ Jülich)
11:45 AM Short Talk
11:45 AM - 12:30 PM
Room: Lecture Hall
Contributions

11:45 AM In situ structure of a gap junction - stomatin complex. - Alexander Gottschalk (Goethe University)

12:05 PM Insights into the plasma membrane association of Extended Synaptotagmin 3 - Veronika Thallmair (Philipps University Marburg)
12:30 PM LUNCH BREAK
LUNCH BREAK
12:30 PM - 2:00 PM
2:00 PM Invited Talks
2:00 PM - 2:45 PM
Room: Lecture Hall
Contributions

2:00 PM Digital Twins in biology and medicine: bridging experimental models, simulation, and health systems - Liesbet Geris (University of Liège, KU Leuven, VPH society)
2:45 PM Panel discussion: Digital twins - Criteria, Chances and Challenges
2:45 PM - 3:30 PM
Room: Lecture Hall
Contributions

2:45 PM Digital Twins – Criteria, Chances and Challenges
3:30 PM Coffee Break
Coffee Break
3:30 PM - 4:00 PM
Room: Lecture Hall
4:00 PM Short Talk
4:00 PM - 4:45 PM
Room: Lecture Hall
Contributions

4:00 PM Data Driven Modelling of Limb Bud Growth and Morphogenesis - Tim Liebisch (EMBL Barcelona)

4:20 PM Initiative of Panoramic Digital Life Model Project - Liangyi Chen (National Biomedical Imaging Center, Peking University)
4:45 PM Invited Talks
4:45 PM - 5:30 PM
Room: Lecture Hall
Contributions

4:45 PM Building a Virtual Embryo - A Single Cell At a Time. - Loic Royer (Biohub)
5:30 PM Short Talk
5:30 PM - 6:15 PM
Room: Lecture Hall
Contributions

5:30 PM Multiscale Investigation of Membrane Remodeling during Selective ER-phagy - Ramachandra M. Bhaskara (Goethe University)

5:50 PM Molecular Digital Twins of Innate Immunity: Insights from Simulations of Human Guanylate-Binding Protein 1 - Birgit Strodel (FZ Jülich)
6:15 PM CONFERENCE DINNER

6:15 PM - 7:15 PM
Thursday, March 5, 2026
9:00 AM Invited Talks
9:00 AM - 10:30 AM
Room: Lecture Hall
Contributions

9:00 AM Teaching AI the Language of RNA: Foundation Models for Regulation and Therapeutic Design - Annalisa Marsico (Computational Health Center, Helmholtz Munich)

9:45 AM Mining Molecular Data: from Single Cell Genomics to Cryo-E - Judith Zaugg (University of Basel)
10:30 AM Coffee Break
Coffee Break
10:30 AM - 11:00 AM
Room: Lecture Hall
11:00 AM Short Talk
11:00 AM - 11:45 AM
Room: Lecture Hall
Contributions

11:00 AM Nuclear speckle periphery organizes stable intron-retained RNAs into a distinct nuclear retention compartment - Josep BIayna (Goethe University)

11:20 AM From Capability to Confidence: RNA Mass Spectrometry as a Criterion for Digital Twins - Stefanie Kaiser (Goethe University)
11:45 AM Invited Talks
11:45 AM - 12:30 PM
Room: Lecture Hall
Contributions

11:45 AM Digital twins for modelling gene expression: applications to association studies and personalized drug recommendation - Marcel Schulz (Goethe University and Uniklinikum Frankfurt)
12:30 PM Lunch Break
Lunch Break
12:30 PM - 2:00 PM
Room: Lecture Hall
2:00 PM Short Talk
2:00 PM - 2:45 PM
Room: Lecture Hall
Contributions

2:00 PM Molecular mechanism of membrane pore formation triggered by PI(4,5)P2- dependent FGF2 oligomerization - Fabio Lolicato (Heidelberg University)

2:20 PM Learning Biomolecular Ensembles from Experimental Cryo-EM Data - Lars Dingeldein (FIAS)
2:45 PM Invited Talks
2:45 PM - 3:30 PM
Room: Lecture Hall
Contributions

2:45 PM Insights into the mitochondrial collective - Suliana Manley (EPFL - Laboratory of Experimental Biophysics Lausanne)
3:30 PM Coffee Break
Coffee Break
3:30 PM - 4:00 PM
Room: Lecture Hall
4:00 PM Short Talk
4:00 PM - 4:45 PM
Room: Lecture Hall
Contributions

4:00 PM The role of SAM domain in ΔNp63α - Srilakshmi Kalathil (Goethe University)

4:20 PM Parameterization of Molecular Photoswitches for Martini 3 and their Application in Photopharmacology - Thilo Duve (FIAS)
4:45 PM Invited Talks
4:45 PM - 6:15 PM
Room: Lecture Hall
Contributions

4:45 PM If Machines Can Learn, Who Needs Scientists? - Jeffery Hoch (UConn Health)

5:30 PM In-cell structural systems modeling - Jan Kosinski (EMBL)
6:15 PM Closing Remarks

6:15 PM - 7:15 PM
Room: Lecture Hall