Name: Giersch International Conference & SCALE Kick-Off
Start: 2026-03-02T09:00:00+01:00
End: 2026-03-05T19:15:00+01:00
Location: FIAS / OSZ

Giersch International Conference & SCALE Kick-Off

from Monday, 2 March 2026 (09:00) to Thursday, 5 March 2026 (19:15)

Monday, 2 March 2026

16:00 Welcome: Registration and Coffee
Registration and Coffee
16:00 - 17:00
Room: Lecture Hall

17:00 Welcome: Opening Remarks
Opening Remarks
17:00 - 17:20
Room: Lecture Hall
17:20 Invited Talks
17:20 - 18:50
Room: Lecture Hall
Contributions

17:20 Toward Digital Twins of Development and Disease - Dagmar Iber (ETH Zürich)

18:05 Integrative Structural Biology in the era of Artificial Intelligence - Max Bonomi (Institut Pasteur)
19:00 Welcome: Reception
Reception
19:00 - 20:30
Room: Faculty Club
Tuesday, 3 March 2026
09:00 Invited Talks
09:00 - 10:30
Room: Lecture Hall
Contributions

09:00 How cellular architecture modulates drug response - Stefan Knapp (Goethe University)

09:45 Bayesian metamodeling of early T-cell antigen receptor signaling accounts for its nanoscale activation patterns - Barak Raveh (The Hebrew University of Jerusalem)
10:30 Coffee Break
Coffee Break
10:30 - 11:00
Room: Lecture Hall
11:00 Short Talk
11:00 - 11:45
Room: Lecture Hall
Contributions

11:00 From in situ cryoET to digital twins of subcellular segments - Sergio Cruz-Leon (Max Planck Institute of Biophysics)

11:20 Control of the condensation of TDP-43 by enzymatic phosphorylation: a perspective from molecular dynamics simulations - Lukas Stelzl (Johannes Gutenberg University Mainz & IMB)
11:45 Invited Talks
11:45 - 12:30
Room: Lecture Hall
Contributions

11:45 Computational tools for building models of entire biological systems from light and electron microscopy - Stephan Preibisch (HHMI Janelia)
12:30 LUNCH BREAK
LUNCH BREAK
12:30 - 14:00
14:00 Invited Talks
14:00 - 15:30
Room: Lecture Hall
Contributions

14:00 From integrative structural biology to cell biology - Andrej Sali (UCSF)

14:45 Biomolecular condensate architecture of an autophagic cargo at molecular resolution in situ - Florian Wilfing (Max Planck Institute of Biophysics)
15:30 Coffee Break
Coffee Break
15:30 - 16:00
Room: Lecture Hall
16:00 Short Talk
16:00 - 16:45
Room: Lecture Hall
Contributions

16:00 Multiscale Modeling of Nuclear Membrane Sealing - Karen Palacio-Rodriguez (Max Planck Institute of Biophysics)

16:20 Deep-SegCLEM: unified segmentation and matching for correlative light–electron microscopy - Soumaya Zaghbani (Max Planck Institute of Biophysics)
16:45 Invited Talks
16:45 - 18:15
Room: Lecture Hall
Contributions

16:45 Towards Digital Twins of Nuclear Pores - Martin Beck (Max Planck Institute of Biophysics)
18:15 POSTER SESSION

18:15 - 19:45
Room: Room 0.101 (next to lecture hall)
Wednesday, 4 March 2026
09:00 Invited Talks
09:00 - 09:45
Room: Lecture Hall
Contributions

09:00 Using digital twins to probe the origins of intelligence - Samantha Wood (Indiana University Bloomington)
09:45 Short Talk
09:45 - 10:30
Room: Lecture Hall
Contributions

09:45 rRNA expansion segments mediate the oligomerization of inactive animal ribosomes - Mara Müller (MPI for Brain Research)

10:05 Area-specific signatures of time-irreversibility in spontaneous neural activity of the mouse brain - Jonas Elpelt (FIAS)
10:30 Coffee Break
Coffee Break
10:30 - 11:00
Room: Lecture Hall
11:00 Invited Talks
11:00 - 11:45
Room: Lecture Hall
Contributions

11:00 Towards Digital Twins of the cerebral cortex - Sasha van Albada (FZ Jülich)
11:45 Short Talk
11:45 - 12:30
Room: Lecture Hall
Contributions

11:45 In situ structure of a gap junction - stomatin complex. - Alexander Gottschalk (Goethe University)

12:05 Insights into the plasma membrane association of Extended Synaptotagmin 3 - Veronika Thallmair (Philipps University Marburg)
12:30 LUNCH BREAK
LUNCH BREAK
12:30 - 14:00
14:00 Invited Talks
14:00 - 14:45
Room: Lecture Hall
Contributions

14:00 Digital Twins in biology and medicine: bridging experimental models, simulation, and health systems - Liesbet Geris (University of Liège, KU Leuven, VPH society)
14:45 Panel discussion: Digital twins - Criteria, Chances and Challenges
14:45 - 15:30
Room: Lecture Hall
Contributions

14:45 Digital Twins – Criteria, Chances and Challenges
15:30 Coffee Break
Coffee Break
15:30 - 16:00
Room: Lecture Hall
16:00 Short Talk
16:00 - 16:45
Room: Lecture Hall
Contributions

16:00 Data Driven Modelling of Limb Bud Growth and Morphogenesis - Tim Liebisch (EMBL Barcelona)

16:20 Initiative of Panoramic Digital Life Model Project - Liangyi Chen (National Biomedical Imaging Center, Peking University)
16:45 Invited Talks
16:45 - 17:30
Room: Lecture Hall
Contributions

16:45 Building a Virtual Embryo - A Single Cell At a Time. - Loic Royer (Biohub)
17:30 Short Talk
17:30 - 18:15
Room: Lecture Hall
Contributions

17:30 Multiscale Investigation of Membrane Remodeling during Selective ER-phagy - Ramachandra M. Bhaskara (Goethe University)

17:50 Molecular Digital Twins of Innate Immunity: Insights from Simulations of Human Guanylate-Binding Protein 1 - Birgit Strodel (FZ Jülich)
18:15 CONFERENCE DINNER

18:15 - 19:15
Thursday, 5 March 2026
09:00 Invited Talks
09:00 - 10:30
Room: Lecture Hall
Contributions

09:00 Teaching AI the Language of RNA: Foundation Models for Regulation and Therapeutic Design - Annalisa Marsico (Computational Health Center, Helmholtz Munich)

09:45 Mining Molecular Data: from Single Cell Genomics to Cryo-E - Judith Zaugg (University of Basel)
10:30 Coffee Break
Coffee Break
10:30 - 11:00
Room: Lecture Hall
11:00 Short Talk
11:00 - 11:45
Room: Lecture Hall
Contributions

11:00 Nuclear speckle periphery organizes stable intron-retained RNAs into a distinct nuclear retention compartment - Josep BIayna (Goethe University)

11:20 From Capability to Confidence: RNA Mass Spectrometry as a Criterion for Digital Twins - Stefanie Kaiser (Goethe University)
11:45 Invited Talks
11:45 - 12:30
Room: Lecture Hall
Contributions

11:45 Digital twins for modelling gene expression: applications to association studies and personalized drug recommendation - Marcel Schulz (Goethe University and Uniklinikum Frankfurt)
12:30 Lunch Break
Lunch Break
12:30 - 14:00
Room: Lecture Hall
14:00 Short Talk
14:00 - 14:45
Room: Lecture Hall
Contributions

14:00 Molecular mechanism of membrane pore formation triggered by PI(4,5)P2- dependent FGF2 oligomerization - Fabio Lolicato (Heidelberg University)

14:20 Learning Biomolecular Ensembles from Experimental Cryo-EM Data - Lars Dingeldein (FIAS)
14:45 Invited Talks
14:45 - 15:30
Room: Lecture Hall
Contributions

14:45 Insights into the mitochondrial collective - Suliana Manley (EPFL - Laboratory of Experimental Biophysics Lausanne)
15:30 Coffee Break
Coffee Break
15:30 - 16:00
Room: Lecture Hall
16:00 Short Talk
16:00 - 16:45
Room: Lecture Hall
Contributions

16:00 The role of SAM domain in ΔNp63α - Srilakshmi Kalathil (Goethe University)

16:20 Parameterization of Molecular Photoswitches for Martini 3 and their Application in Photopharmacology - Thilo Duve (FIAS)
16:45 Invited Talks
16:45 - 18:15
Room: Lecture Hall
Contributions

16:45 If Machines Can Learn, Who Needs Scientists? - Jeffery Hoch (UConn Health)

17:30 In-cell structural systems modeling - Jan Kosinski (EMBL)
18:15 Closing Remarks

18:15 - 19:15
Room: Lecture Hall

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