Speaker
Dr
Naresh Yandrapalli
(Saarland University)
Description
Synthetic cells are vital for modeling cellular complexity. We present a progressive inverted emulsion method that transitions from robust on-chip vesicle production to engineering complex bilayers with ~95% asymmetry. By integrating lateral phase-separation ($L_o$/$L_d$ domains) and domain-specific protein binding , we induce spontaneous curvature leading to autonomous budding and fission. These biomimetic models provide essential experimental benchmarks for digital twins in structural cell biology.