Speaker
Mr
Plamen Kondev
(Goethe University Frankfurt)
Description
Membrane remodeling underlies many eukaryotic processes and is presumed to have co-evolved with the ER. We characterize six protein families that contain the Reticulon and Reticulon-like domains across all sequenced genomes. We present a new sequence-based subfamily classification. Despite poor sequence conservation across various phyla, this classification correlates with distinct changes in membrane-shaping elements (TM hairpins and AH segments) and their physico-chemical properties.