Speaker
Mr
Alberto Cristiani
(Goethe University Frankfurt)
Description
E3 ubiquitin ligases define the ubiquitin code, regulating protein degradation and non-degradative processes such as DNA repair, signaling, and immunity. We present a comprehensive classification of the human E3 ligome by integrating sequence, structural, functional, and expression data using a weakly supervised metric-learning framework. This approach captures relationships across E3 families, extends canonical classes, and maps E3s to substrates and therapeutic opportunities.