Speaker
Prof.
Stefanie Kaiser
(Goethe University)
Description
Digital twins in structural cell biology critically depend on experimental data quality and interpretability. RNA is a central molecular layer, yet its mass spectrometric analysis remains analytically fragile. I will discuss why RNA-MS cannot be treated as an extension of proteomics and how intrinsic ambiguity, redundancy, and modification complexity challenge confidence. I argue that explicit analytical control and RNA-aware validation criteria are essential for integrating RNA into mechanistically meaningful digital twins.