Speaker
Dr
Ramachandra M. Bhaskara
(Goethe University)
Description
FAM134B drives selective ER-phagy to maintain ER homeostasis. Modeling, coarse-grained MD, and experiments capture RHD-driven curvature induction/sensing (isoform-specific), ubiquitination-triggered clustering, and IDR-amplified ER budding. These self-organizing principles inform a hierarchical digital twin of the ER–phagophore contact site linking membrane mechanics/curvature, FAM134B–LC3B tethering, and ATG9-mediated lipid scrambling to predict nascent phagophore recruitment, growth, and maturation.