Dynamics of biological systems: emergent phenomena at different scales

Session

Patterns in Biology

Patterns in Biology

1 Dec 2023, 16:00

A-1-06 (Jagiellonian University)

Conveners

Patterns in Biology: Part I

• Marcin Zagorski

Patterns in Biology: Part II

• Katarzyna Dziedzic-Kocurek (M. Smoluchowski Institute of Physics, Jagiellonian University)

11. From cell mechanics to tissue-scale properties properties in development

bernat corominas-murtra (University of Graz)

01/12/2023, 16:00

The developmental process implies precise but significant changes in the geometry and structure of the embryonic tissues. Recent results show that apparently minor changes in the mechanical properties at the cellular level trigger deep, non-linear transitions in the topological organization of the whole embryonic tissue. In consequence, the tissue changes its material properties abruptly,...

7. A Clock and Wavefront Self-Organizing model explains somitogenesis in vivo and in vitro

Luciano Marcon (Andalusian Center for Developmental Biology)

01/12/2023, 16:45

During mouse development, presomitic mesoderm cells synchronize Wnt and Notch oscillations, forming sequential waves that pattern somites. Classical somitogenesis models attribute these synchronizations to global morphogen gradients. However, increasing evidence suggests that they could arise in a self-organizing manner. Here, we introduce the Sevilletor, a novel reaction-diffusion system that...

2. Stability of gene expression patterns in developmental systems with dynamic morphogen sources

Maciej Majka

01/12/2023, 17:30

In developmental systems cells determine their fate by decoding chemical signals, called morphogens. This results in the emergence of gene expression patterns. I will address the problem of gene expression patterns stability in the systems where two interacting and diffusible gene expression products control the size of their own source regions. Such systems are encountered in e.g. spinal cord...

18. Novel studies of cancer cells heterogeneity

Zenon Rajfur (Department of Molecular and Interfacial Biophysics, Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, ul. Lojasiewicza 11, 30‑348 Kraków, Poland)

02/12/2023, 09:30

The phenomenon of cellular heterogeneity - the presence of diverse subpopulations in the cell lines cultures - is the subject of many recent studies. This effect is especially pronounced in the cancer cells populations which, in turn, can influence the outcome of anticancer therapies. It is postulated that heterogeneity is the result of long term evolution of cell types. However, heterogeneity...

13. Mathematical modelling of cancer invasion: Phenotypic transitioning provides insight into multifocal foci formation

Zuzanna Szymańska (ICM, University of Warsaw)

02/12/2023, 10:15

The transition from the epithelial to mesenchymal phenotype and its reverse (from mesenchymal to epithelial) are crucial processes necessary for the progression and spread of cancer. We investigate how phenotypic switching at the cancer cell level impacts the behaviour at the tissue level, specifically on the emergence of isolated foci of the invading solid tumour mass leading to a multifocal...