Speaker
Description
Drug delivery system (DDS) has been extensively interested in scientific area such as medical science, environment, industry, agriculture and food processing. In this work, nanobubble (NB) was developed as carrier in the DDS and applied in the niosome particle. The DDS had been prepared by jointing of MNB technology, mechanical technique (ball milling) and niosome particle. Drug particle consists of NB (carrier), surfactant (span 60), additive (cholesterol) and drug (melatonin). Stability and viability of the drug particle system had been defined by size and zeta potential for a moth which measured every week (total 5 times in a month). The size and zeta potential had been measured by the dynamics light scattering (Malvern Zetasizer analyzer). Melatonin encapsulation was measured by the dialysis method. The particle sizes and zeta potential of the drug particle system are an average 300 nm and -30 mV, respectively. And melatonin encapsulations are about 60%. From results can be concluded that the conditions of surfactant at span60 : cholesterol molar ratio of 1.5 : 0.5 is a proper condition. And all conditions are stability for a month as the NB carrier in drug particle system.
Keyword: Drug delivery system, Nanobubble, Niosome, Melatonin
