Speaker
Description
Cholangiocarcinoma (CCA), also known as bile duct cancer, is a silent cancer that is difficult to treat because patients are diagnosed at an advanced stage with incurable disease. Chemotherapy and radiotherapy are additional treatments options for these patients that can help improve their quality of life and survival. Nowadays, radiotherapy utilizing proton beams is gaining interest in the treatment of cancers, including CCA. The purpose of this work is to investigate the radiobiological attributes of CCA cell lines (KKU-213) by observing the response of CCA cells to photons and protons irradiation. KKU-213 cells were cultured in monolayers and cells have been irradiated using 6 MV LINAC and 100 MeV proton beams with dose ranging from 0 – 5 Gy. Measured dose response curves from both photons and protons irradiation were then compared in order to obtain the relative biological effectiveness (RBE) values. By obtaining the RBE value, we could determine whether proton beams would be an alternative approach for CCA treatment.
