Conveners
T: Radiobiology
- Ana Vega
Radiotherapy (RT) is a well-established medical modality that is delivered to more than 50% of cancer patients at some point of their treatment. Additionally, RT has been successfully used to treat extra-cranial amyloidosis and current evidence indicates that is a promising treatment for amyloid-associated neurodegenerative disorders such as Alzheimer’s, Parkinson's, and Huntington's diseases....
The radiobiological experiments show that in order to make an adequate correspondance between the biological effects and the dosimetric measurements it is necessary to have a high resolution dose map (~ microns). Having this in mind a project is being developed at Laboratório de Instrumentação e Física Experimental de Partículas (LIP), in Portugal, that aims at the development of a detector to...
DNA damage produced by ionizing radiation can be divided into two categories: lethal and sublethal lesions. Lethal lesions are those that result directly in cell death. Sublethal lesions do not result in immediate cell death but may combine to become a lethal lesion after a period or may be repaired by the cell. The spatial distribution of damage, and hence the distribution of deposited...
Introduction: Proton therapy makes it possible to achieve coverage levels for target volumes similar to the most advanced gamma radiotherapy techniques, irradiating significantly less healthy tissue. In addition, numerous publications suggest that proton irradiation produces a high biological effect. On the other hand, Monte Carlo (MC) simulation is accepted as the most accurate tool for...
The unique properties of protons allow the treatment of specific areas avoiding surrounding tissues due to the deposition in depth of the dose and the different values of Linear Energy Transfer (LETs) along this deposition. The effect of protons is due to a high LET compared to the conventional radiotherapy and the relative biological effectiveness (RBE) as a function of LET is described to be...
