Conveners
W-POS-D #17-27,110 Poster session (DPMB) / Session d'affiches (DPMB)
- Emily Heath
W-POS-D #17-27,110 Poster session (DPMB) / Session d'affiches (DPMB)
- Emily Heath
Laser-induced breakdown spectroscopy (LIBS) is a laser-based spectrochemical technique that allows a near-instantaneous measurement of the elemental composition of a target by making time-resolved spectroscopic analyses of laser-induced ablation plasmas. Utilizing nanosecond laser pulses and a broadband high-resolution Echelle spectrometer, high signal-to-noise optical emission spectra can be...
Development of portable X-ray fluorescence devices has made it easier to quickly assess trace elements such as zinc in human tissue. Zinc deficiency can have serious implications on growth and development of the human body. From recent studies zinc content in nail clippings has been suggested to be an effective biomarker for zinc status. In this study, a simulation approach was used to...
RATIONALE: Hyperpolarized gas MRI is a powerful tool to track lung progression using biomarkers (ADC and mean linear intercept estimate (Lm)). Sometimes, longitudinal observations can lead to problematic values, as the disease progression can lead to increasing unventilated lung areas, which likely excludes the largest3 ADC/Lm values. We hypothesize that this morphometry method can provide an...
Understanding the physical limitations and trade-offs related to suppressing fluctuations in stochastic cellular processes is of great importance for systems and synthetic biology applications. We show that a generic class of complex formation processes in which two subunits associate to form a complex is constrained by a trade-off between the subunit fluctuations and the efficiency of complex...
Effect of Lung Surfactant Protein B Fragment, SP-B1-9 on Model Lipid Bilayer.
Abinu, MHK, ISV, MRM
Lung surfactant is a mixture of protein and lipid that reduces surface tension at the air-water interface in the lungs and thus reduces the work needed to breathe. Two hydrophobic proteins, SP-B and SP-C, are thought to facilitate the re-spreading of fresh and recycled surfactant material...
We use dynamical self-consistent field-theory simulations of interacting, self-propelled rods to study the fascinating time-dependent, inhomogeneous structures observed during the growth of a colony of twitching Pseudomonas aeruginosa bacteria confined at the interface between a glass substrate and agar. These collective patterns in colony growth are relevant to early-stage biofilm...
Bioanalytical sensors based on field-effect transistors (bioFETs) are emerging as promising tools to measure the kinetics of biopolymers such as proteins and DNA strands. This class of biosensors is based on an ultra-miniaturized electronic circuit whose conductance is very sensitive to the variations of the electrostatic potential in its environment caused by conformational changes in the...
A prototype medical device has been developed and built at Western University to image adolescents with hemophilic arthropathy. The device consists of a plastic cylindrical tub able to rotate freely about a base plate. A 10 MHz linear array ultrasound transducer by Canon Medical Systems is mounted to the inside of the tub pointed toward its center. The tub is filled with water to act as a...
Autopsy studies indicate that the distribution of axons throughout the brain could differ in brains with and without schizophrenia. MRI has inferred axon diameters and distribution in the brain, typically for axons larger than 5 μm in diameter. The goal of this work is to modify these methods to adapt oscillating gradients (OG) to target small axons (1 to 2 μm range) which constitute the...
The human brain is a magnificent system with highly complex functionalities such as learning, memory, emotion, and subjective experience. Over the past decades, it has been proposed that quantum physics could help answer unsolved questions in life science. Here we present a quantum model that could shed light on the mechanisms behind xenon-induced anesthesia and the lithium effects on...
