Speaker
Description
Optogenetics is an exciting field that combines optics with biology and genetic engineering. One of the main subjects of study in optogenetics are methods to control the activation of nerve cells with light. A device that can leverage the ability of optogenetics to control organs that are normal regulated by the parasympathetic nervous system will allow us to deliver new forms of medical treatments such as; pain and hungry suppression or control over breathing and gut peristalsis. However there has not been much success in applying these tools chronically. There are several hurdles limiting the viability of a long-term implantable device that leverages the power of optogenetic organ control. One of the hurdles limiting the application of optogenetic techniques in areas like the peripheral nervous system is the current light delivery method. For these applications implantable waveguides need to be compliant as a high difference in stiffness between the surrounding tissue relative to the waveguide will cause damage to those tissues during movement and cause a negative immune response. The waveguide will also need to be elastic as this movement can cause the waveguide to fail if it stretches past its physical limit. Electrically sensed feedback is also important to ensure that the optical stimulation is working as intended. Our work centres on the creation of a prototype lead that will combine both electrical and optical delivery means in a compliant but robust package that will enable further development in the realm of optogenetic based medical treatments. We have investigated the suitability of both Ormocer and high refractive index silicone for implantable waveguide applications in terms of optical and mechanical properties after exposure to simulated body fluid and have developed a simplified gold electrode fabrication method which can be expanded to include the optical component.
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