Speaker
Description
Radionuclides that decay with Meitner-Auger electrons are believed to have potential in targeted radionuclide therapy, due to their short ranges on the scale of the cellular nucleus with high precision dose delivery. To establish production routes, accurate nuclear data for optimization of irradiation and yield predictions are required. The Meitner-Auger emitter $^{193m}$Pt is of interest due to its therapeutic potential particularly labelled to the chemotherapeutic drug cisplatin, which may streamline treatment and also avoid chemical toxicity.
A stacked target irradiation was performed at Lawrence Berkeley National Laboratory’s 88-Inch Cyclotron. The stack included 10 foils of iridium, with monitor foils of nickel, copper and iron placed within each compartment. The stack was irradiated with a 33 MeV deuteron beam, and the beam was completely degraded in the stack, yielding cross section measurements from threshold to 33 MeV. The beam current through the stack was determined using recommended monitor reactions, and energy assignments were obtained through Anderson-Ziegler stopping power simulations. Following end-of-irradiation, gamma-ray spectroscopy was performed to quantify the activities for all observed radionuclides.
This work yielded cross sections for 42 channels of deuteron induced reactions on natural iridium, copper, nickel and iron from threshold to 33 MeV, as well as thick target yields of the measured channels of iridium. I will present the key results of the final cross sections from the iridium targets and monitor foils, and the optimum deuteron energy window to maximize the production and radiopurity of $^{193m}$Pt via this reaction