Speaker
Oskar Ekeid Idland
(Department of Physics, University of Oslo)
Description
Targeted alpha therapy is a new modality of cancer treatment in which alpha-emitters are used to precisely target cancer cells; however the short range of alpha particles makes assessing the actual dose of radiation delivered to the cell challenging. PSMA-targeted $^{212}$Pb radionuclides have previously been clinically investigated for prostate cancer cell lines C4-2, PC3-PIP and PC3-Flu. Clonogenic assays have been performed for different concentrations of radionuclides. In this thesis I will use these experiments as constraints to perform GEANT4 Monte Carlo particle transport simulations. This allows me to investigate energy depositions in different parts of the cell, with special attention to the nucleus, where DNA resides.
Author
Oskar Ekeid Idland
(Department of Physics, University of Oslo)