Bisexual flowering plants are at high risk of self-fertilization, which would produce less fit offspring (known as ‘inbreeding depression’). Hence, more than 100 flowering plant families have developed various mechanisms to avoid self-fertilization, generally called ‘self-incompatibility’ (SI). Under these mechanisms, the species is subdivided into multiple 'types' or 'classes', such that a...
The human immune system consists of lymphoid tissue in different localisations, including about 600 lymph nodes. The latter can be divided in different compartments, concentrating specialised immune cells in a highly effective manner. We investigated and defined human lymph nodes applying confocal laser technologies to generate 3-D pictures and 4Dmovies. Many parameters as cell speeds tracks...
Data analytics requires large data archives beyond current world storage media, causing researchers to seek alternative storage media. Scientists in fields like biology, ecology, life sciences, and medicine are using data archiving to aid their research. During the last decade, DNA (Deoxyribonucleic Acid) storage has been significantly investigated as a method for archiving data at massive...
This presentation explores advanced topics in the simulation of biochemical systems, with a particular emphasis on multiscale approaches for modeling open systems characterized by varying particle/molecule numbers. We will discuss key methods, including hybrid and coarse-grained simulation schemes, as well as the integration of thermodynamic principles and field theory representations to...
Molecular dynamics simulations with atomistic resolution are a standard tool to study liquids and biomolecular systems. Most often, force field (FF) limitations mean that simulations must be performed at low concentrations. I will discuss recent advances in FFs of ions and the insight they enabled into the molecular scale mechanisms leading to protein halophilicity, as well as the...
