Purpose: In quantitative nuclear medicine, the displacement of the positron before annihilation induces a loss of spatial resolution. As the size of the detectors decreases, this effect becomes non-negligible. In this presentation, I shall address a method of quantifying the displacement of the positron, especially its impacts on the segmentations in dynamic acquisitions. This method takes...
Brain metastases have been effectively treated with stereotactic radiosurgery (SRS) delivered to visible growths followed by whole brain radiotherapy (WBRT) for microscopic disease. SRS alone is the preferred treatment despite high recurrence, as conventional WBRT is associated with increased cognitive decline. With improved systemic treatments breast cancer patients are living longer...
Tumour associated macrophages (TAMs) constitute up to 50% of the breast cancer microenvironment and are linked to adverse patient outcomes. Conventionally, TAM density is assessed through immunohistochemistry (IHC); however, this relies on invasive biopsies and is not representative of the entire tumour. Thus, there is a need for non-invasive, quantitative imaging for in vivo TAM assessment....
Magnetic resonance imaging generates image contrast via interactions between the nuclear magnetic moment of atoms and applied magnetic fields. Hydrogen has a non-zero magnetic moment and is abundant in the water within human tissue, making it the predominant source of signal in MRI. Moreover, the active nature of MRI, where the spins are “excited” and then the magnetic fields they emit are...
Background
Sodium (23Na) magnetic resonance imaging (MRI) can detect the increased tissue sodium concentration (TSC) exhibited in several tumour types. For prostate cancer imaging, 23Na MRI is conventionally performed using an endorectal coil which is associated with a nonuniform sensitivity profile and limited field of view, constraining its clinical utility. To address these challenges,...
