2024 CAP Congress / Congrès de l'ACP 2024

Session

(DPMB) T3-3 Biomolecular Condensates | Condensats biomoléculaires (DPMB)

T3-3

28 May 2024, 16:15

Western University

4553. The intrinsically disordered variable domain from dynamin-related protein 1 promotes liquid–liquid phase separation that enhances dynamin assembly and its interaction with cardiolipin-containing membranes

James Harden (Department of Physics, University of Ottawa)

28/05/2024, 16:15

Physics in Medicine and Biology / Physique en médecine et en biologie (DPMB-DPMB)

Invited Speaker / Conférencier(ère) invité(e)

Dynamins are an essential superfamily of mechanoenzymes that remodel membranes and often contain a “variable domain” important for regulation. For the mitochondrial fission dynamin, dynamin-related protein 1 (Drp1), a regulatory role for the variable domain (VD) is demonstrated by gain- and loss- of-function mutations, yet the basis for this is unclear. Here, the isolated VD is shown to be...

4243. Retinal protein deposits identified using polarized light, as biomarkers of multiple neurodegenerative brain diseases

Prof. Melanie CW Campbell (University of Waterloo)

28/05/2024, 16:45

Symposia Day (DPMB/DAPI - DPMB/DPAI) - Medical Imaging / Imagerie médicale

Invited Speaker / Conférencier(ère) invité(e)

Introduction: We have previously demonstrated, using polarized light, that we can image amyloid protein deposits in the retina without a dye. Postmortem, their numbers predict the load of amyloid in the brain and severity of Alzheimer’s disease (AD). Here we differentiate retinal deposits of presumed amyloid beta, associated with AD, from presumed retinal deposits of alpha synuclein,...

4309. (G*) Significant Effects of Protonation on the Nature and Kinetics of Isomerization in Molecular Azo Photoswitches

Coral Hillel (York University)

28/05/2024, 17:15

Physics in Medicine and Biology / Physique en médecine et en biologie (DPMB-DPMB)

Oral Competition (Graduate Student) / Compétition orale (Étudiant(e) du 2e ou 3e cycle)

Molecular azobenzene photoswitches have long been attractive in the design of photoresponsive materials owing to their reversible light-triggered photoisomerization about the azo bond (N=N) between trans and cis isomeric configurations. Towards more versatile materials applications, azopyridines have been designed as a next-generation azobenzene photoswitch possessing pH sensitivity,...

4240. (G*) Optical fiber holder for FLASH dosimetry at a medical cyclotron

Janina Hohnholz (Faculty of Chemistry and Biotechnology, University of Applied Sciences Aachen & TRIUMF)

28/05/2024, 17:30

Physics in Medicine and Biology / Physique en médecine et en biologie (DPMB-DPMB)

Oral Competition (Graduate Student) / Compétition orale (Étudiant(e) du 2e ou 3e cycle)

Proton therapy uses an external beam of protons to destroy cancerous tissue while reducing damage to healthy tissue. Of particular interest is the recent concept of proton FLASH therapy, where ultra-high dose rates (> 40 Gy/s) are delivered for under one second, with improved sparing of healthy tissue compared to conventional dose rates. The FLASH effect and the influence of beam properties...