2024 CAP Congress / Congrès de l'ACP 2024

Session

(DPMB) T1-3 Chemical physics in biology and medicine | Physique chimique en biologie et en médecine (DPMB)

T1-3

28 May 2024, 10:30

Western University

4442. (G*) Solubilization of Hydrophobic Astaxanthin in Water by Physical Association with Phytoglycogen Nanoparticles

Nicholas van Heijst

28/05/2024, 10:30

Physics in Medicine and Biology / Physique en médecine et en biologie (DPMB-DPMB)

Oral Competition (Graduate Student) / Compétition orale (Étudiant(e) du 2e ou 3e cycle)

Phytoglycogen (PG) is a naturally occurring polysaccharide produced as compact, highly branched nanoparticles in the kernels of sweet corn. Because PG is biocompatible, non-toxic and digestible, it is attractive for applications involving the delivery of bioactive compounds. In the present study, we evaluate the association of PG with the hydrophobic bioactive astaxanthin (AXT), which is a...

4330. (G*) Real-time behavior of radiochromic materials in standard proton and photon, and electron FLASH beams

Rohith Kaiyum

28/05/2024, 10:45

Symposia Day (DPMB/DAPI - DPMB/DPAI) - Medical Imaging / Imagerie médicale

Oral Competition (Graduate Student) / Compétition orale (Étudiant(e) du 2e ou 3e cycle)

Purpose: With advancements in high dose rate radiotherapy techniques such as FLASH therapy, radiochromic films have been proposed as a key dosimeters due to their relative dose rate independence when used with standard read-out methods. Our group is interested in understanding the real-time behaviour of these materials in order to develop radiochromic optical probes for real-time dosimetry,...

4119. (G*) Harnessing Electrochemistry with Surface-Enhanced Raman Spectroscopy for the Analysis of Hemoglobin Defects on Plasmonic Nanostructured Films

Janani Balasubramanian

28/05/2024, 11:00

Physics in Medicine and Biology / Physique en médecine et en biologie (DPMB-DPMB)

Oral Competition (Graduate Student) / Compétition orale (Étudiant(e) du 2e ou 3e cycle)

Hemoglobin (Hb), the cornerstone of oxygen transport in the body, holds crucial diagnostic significance for disorders like β-Thalassemia and sickle cell anemia. Conventional blood assays often grapple with issues of delays, cost, and accessibility. In this study, we unveil an innovative nano-biosensor leveraging surface-enhanced Raman spectroscopy (SERS), offering swift and real-time detection...

4450. (G*) Non-invasive optical monitoring of peripheral and cerebral vasomotion in early sepsis

Rasa Eskandari

28/05/2024, 11:15

Physics in Medicine and Biology / Physique en médecine et en biologie (DPMB-DPMB)

Oral Competition (Graduate Student) / Compétition orale (Étudiant(e) du 2e ou 3e cycle)

Introduction: Sepsis is a life-threatening host response to an infection that disproportionately affects vulnerable and low-resource populations. Since early intervention increases survival rate, there is a global need for accessible technology to aid with early sepsis identification. Peripheral microvascular dysfunction (MVD) is an early indicator of sepsis that manifests as impaired...

4449. (G*) Low-Frequency Oscillations in Cerebral Microvascular Perfusion, Oxygenation, and Metabolism in Mild-Cognitive Impairment Patients

Farah Kamar

28/05/2024, 11:30

Physics in Medicine and Biology / Physique en médecine et en biologie (DPMB-DPMB)

Oral Competition (Graduate Student) / Compétition orale (Étudiant(e) du 2e ou 3e cycle)

Introduction: A promising approach for detecting early-stage mild cognitive impairment (MCI) is identifying changes in cerebrovascular regulation prior to overt changes in cognition. Low-frequency oscillations (LFO) in cerebral perfusion and oxygenation, originating from neurogenic and myogenic regulation of hemodynamics, may be altered in patients with MCI. Previous work has shown...

4163. (G*) Development of a Non-Contact Experimental Platform for Quantitative Migration and Electrotaxis Analysis of Biological Cells

Mr Nicholas Palmerley (Department of Physics and Astronomy, University of Manitoba, Winnipeg, MB, Canada)

28/05/2024, 11:45

Physics in Medicine and Biology / Physique en médecine et en biologie (DPMB-DPMB)

Oral Competition (Graduate Student) / Compétition orale (Étudiant(e) du 2e ou 3e cycle)

Cell migration is a fundamental process in various physiological scenarios such as cancer metastasis, wound healing, immune responses,and embryonic development. Among the environmental cues, physical factors especially the electric field (EF) have been widely demonstrated to guide the migration of various cell types. EF guided cell migration, termed ‘electrotaxis’, has been traditionally...