Phytoglycogen (PG) is a naturally occurring polysaccharide produced as compact, highly branched nanoparticles in the kernels of sweet corn. Because PG is biocompatible, non-toxic and digestible, it is attractive for applications involving the delivery of bioactive compounds. In the present study, we evaluate the association of PG with the hydrophobic bioactive astaxanthin (AXT), which is a...
Purpose: With advancements in high dose rate radiotherapy techniques such as FLASH therapy, radiochromic films have been proposed as a key dosimeters due to their relative dose rate independence when used with standard read-out methods. Our group is interested in understanding the real-time behaviour of these materials in order to develop radiochromic optical probes for real-time dosimetry,...
Hemoglobin (Hb), the cornerstone of oxygen transport in the body, holds crucial diagnostic significance for disorders like β-Thalassemia and sickle cell anemia. Conventional blood assays often grapple with issues of delays, cost, and accessibility. In this study, we unveil an innovative nano-biosensor leveraging surface-enhanced Raman spectroscopy (SERS), offering swift and real-time detection...
Introduction: Sepsis is a life-threatening host response to an infection that disproportionately affects vulnerable and low-resource populations. Since early intervention increases survival rate, there is a global need for accessible technology to aid with early sepsis identification. Peripheral microvascular dysfunction (MVD) is an early indicator of sepsis that manifests as impaired...
Introduction: A promising approach for detecting early-stage mild cognitive impairment (MCI) is identifying changes in cerebrovascular regulation prior to overt changes in cognition. Low-frequency oscillations (LFO) in cerebral perfusion and oxygenation, originating from neurogenic and myogenic regulation of hemodynamics, may be altered in patients with MCI. Previous work has shown...
Cell migration is a fundamental process in various physiological scenarios such as cancer metastasis, wound healing, immune responses,and embryonic development. Among the environmental cues, physical factors especially the electric field (EF) have been widely demonstrated to guide the migration of various cell types. EF guided cell migration, termed ‘electrotaxis’, has been traditionally...
