Speaker
Navid Afrasiabian
Description
Solid-state nanopore sensors continue to hold great potential in addressing the increasing worldwide need for genome sequencing. However, formation and translocation of folded conformations known as haripins poses readability and accuracy challenges. In this work, we investigate the impact of applying a pressure-driven fluid flow and an opposing electrostatic force as an approach to increase single-file capture probability. By optimizing the balance between forces, we show that the single-file capture can be amplified up to almost 95%. We find two mechanisms responsible for the increase in the single-file capture probability.
| Keyword-1 | Polymer Translocation |
|---|---|
| Keyword-2 | Pulley Effect |
| Keyword-3 | Molecular Dynamics |
Authors
Navid Afrasiabian
Mr
Matthew Wei
(University of Western Ontario)
Colin Denniston
(University of Western Ontario)
