26–31 May 2024
Western University
America/Toronto timezone
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(G) (POS-38) Inferring biochemical reaction rates from stochastic fluctuations in growing and dividing cells

28 May 2024, 17:55
2m
PAB Hallways (Western University)

PAB Hallways

Western University

Poster not-in-competition (Graduate Student) / Affiche non-compétitive (Étudiant(e) du 2e ou 3e cycle) Physics in Medicine and Biology / Physique en médecine et en biologie (DPMB-DPMB) DPMB Poster Session & Student Poster Competition (28) | Session d'affiches DPMB et concours d'affiches étudiantes (28)

Speaker

Linan Shi

Description

We previously introduced an innovative method to convert the co-variability of a pair of species in biochemical networks into biochemical reaction rates without perturbation experiments or relying on time-related data. We demonstrated this method through numerical demonstrations in previous work. However, our previous examples only addressed fluctuations in stationary states of models that overlooked cell division, approximating cellular growth as first-order dilution. In this work, we further exploit non-stationary models involving growing and dividing cells with our previous method. We provide numerical demonstrations where fluctuations in non-stationary systems effectively enabled the inference of rate functions between stochastically interacting elements.

Keyword-1 Fluctuation analysis
Keyword-2 Inference methods
Keyword-3 Complex networks

Authors

Linan Shi Andreas Hilfinger

Presentation materials

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