2018 CAP Congress / Congrès de l'ACP 2018

Session

R2-4 Theoretical and computational biophysics (DPMB) | Biophysique théorique et calculatoire (DPMB)

R2-4

14 Jun 2018, 11:30

Dalhousie University

Conveners

R2-4 Theoretical and computational biophysics (DPMB) | Biophysique théorique et calculatoire (DPMB)

• Christopher Bergevin (York University)

2062. Sequence-specific random-phase-approximation theory for polyampholytic intrinsically disordered proteins in liquid-liquid phase separation

Dr Yi-Hsuan Lin (University of Toronto)

14/06/2018, 11:30

Physics in Medicine and Biology / Physique en médecine et en biologie (DPMB-DPMB)

Oral (Non-Student) / Orale (non-étudiant(e))

Intrinsically disordered proteins (IDPs) are proteins lacking hydrophobic but are enriched in polar, charged, and aromatic amino acids. IDPs do not fold into a unique structure in isolation and often remain disordered in performing biological function. Recently, some IDPs have been discovered to undergo reversible liquid-liquid phase separation (LLPS) in aqueous solution, forming membraneless...

2216. Ratcheting of spherical particles in simple microfluidic devices: making particles move against the direction of the net force

Prof. Gary W. Slater (University of Ottawa)

14/06/2018, 11:45

Physics in Medicine and Biology / Physique en médecine et en biologie (DPMB-DPMB)

Oral (Non-Student) / Orale (non-étudiant(e))

We examine the electrophoresis of charged spherical particles in microfluidic devices made of alternating wells and narrow channels, including a system previously used to separate long DNA molecules. Our computer simulations predict that such systems can be used to separate spherical particles of different sizes that share the same free-solution mobility. Interestingly, the electrophoretic...

2225. Failure of the Ogston Model: Systems with Anisotropic Obstacles and Inhomogeneous Diffusivity

Dr Mehran Bagheri

14/06/2018, 12:00

Physics in Medicine and Biology / Physique en médecine et en biologie (DPMB-DPMB)

Oral (Non-Student) / Orale (non-étudiant(e))

Diffusion plays a critical role in many biological processes, but also in a wide range of experimental devices such as gel electrophoresis and sieving. The well-known Ogston model predicts that the diffusivity of a migrating particle through a random network of fibers (e.g., a gel matrix) is proportional to the fractional volume available to the migrating particle in the given medium. As such,...