Conveners
R3-5 Multimodal and Nonlinear Imaging in Biological Systems (DPMB) | Imagerie multimodale et non-linéaire dans les systèmes biologiques (DPMB)
- Laurent Kreplak (Dalhousie)
Over the years, Second Harmonic Generation (SHG) microscopy has emerged as an effective tool in biology. Like in two-photon excited fluorescence (2P), this type of laser scanning microscopy is characterized by an intrinsic 3D sub-micron resolution that is robust upon light scattering and which allows for higher image depth when compared to confocal microscopy. SHG is a nonlinear optical...
We successfully demonstrate Surface Enhanced-Stimulated Raman Scattering (SE-SRS) using Oxonica (now Cabot securities) nanoparticles for particle concentrations as low as 10 picomolar using peak power densities that are three-to-four orders of magnitude smaller than that required for conventional SRS. These reduced incident powers are possible because the laser field is significantly enhanced...
Osteocytes, the most abundant cells present in bone, regulate bone mass by chemical signaling through the lacunar-canalicular network (LCN). Bone diseases such as Hypophosphatemic Rickets cause painful bone twisting in children, and progress on understanding this disease is slow. The structural and mechanical properties of the LCN are difficult to understand since the LCN is embedded in bone,...
In this contribution, I will discuss the measurements using synchrotron radiation that led to the discovery of a remarkably well preserved skin layer of a hadrosaur from the Grand Prairie region. This is first ever observation of preserved epidermal skin layers in a large dinosaur. I will also present a direct comparison between these structures and those from an extant avian specimen, giving...
