Divisional seminar: Mike Merchant: Mechanistic modelling of DNA & its application to VHEE

Friday 27 Nov 2020, 12:30 → 14:00 Europe/London

https://zoom.us/j/304578256

Divisional seminar.

This seminar discusses how Monte Carlo track structure simulation codes such as Geant4-DNA or Topas-nBio can be used to go beyond linear energy transfer calculations to develop models of DNA damage using nanodosimetry. Nanodosimetry can predict the spectrum of DNA damage that occurs within treatment plans. Understanding the physical qualities of radiation that cause DNA damage is important, but is only half the picture. Coupling DNA damage models to mechanistic models which simulate the DNA repair process can help us understand what physics processes lead to cellular outcomes in terms of survival, chromosome aberration, or other endpoints. The end goal is to develop understand how VHEE treatment plans can be biologically optimised.

Connections will begin at 12:30 with the seminar beginning at 13:00.

ANPP_Merchant_271120_pub.pdf