Speaker
Jakob Schindelwig
(Tu Wien IAP)
Description
Many membraneless compartments of cells, such as stress-granules, form via liquid-liquid phase separation. In cells many compartments of the same type and similar sizes can coexist. Since this is inconsistent with equilibrium phase separation physics, we ask if active mechanics could explain this observation. We develop a model coupling dynamics of the droplet material to an active self-straining filament network. This model shows (i) arrested coarsening , (ii) oscillations, (iii) scale selection. We establish that our model is physiologically plausible by comparing to recent work on a phase separating nucleator of actin.
Authors
Jakob Schindelwig
(Tu Wien IAP)
Quentin Bodini-Lefranc
(Tu Wien, Ecole polytechnique)
Sebastian Fürthauer
(TU Wien)