2026 CAP Congress / Congrès de l'ACP 2026

Session

(DPMB) M3-8 | (DPMB)

M3-8

22 Jun 2026, 16:15

U. Ottawa - Learning Crossroads (CRX) Building

686. Modelling Metamorphic Protein Kinetics in Crowded Cytosolic Environments

Francis Dominie

22/06/2026, 16:15

Physics in Medicine and Biology / Physique en médecine et en biologie (DPMB-DPMB)

Oral Competition (Undergraduate Student) / Compétition orale (Étudiant(e) du 1er cycle)

Cellular interiors are densely crowded with proteins and other macromolecules, leading to excluded-volume and weak enthalpic effects that can strongly modulate protein folding, binding, and aggregation. To study these phenomena, we are developing a combined computational-experimental framework to quantify crowding effects using a well-defined “model cytosol” and a sequence-aware coarse-grained...

805. Coarse- Grained Langevin Dynamics Model for Polyethylene-glycol

Jorja Pevie (Memorial University of Newfoundland)

22/06/2026, 16:30

Physics in Medicine and Biology / Physique en médecine et en biologie (DPMB-DPMB)

Oral Competition (Undergraduate Student) / Compétition orale (Étudiant(e) du 1er cycle)

The interior of cells is a highly dense space in which macromolecules occupy a substantial fraction of the volume. Crowding effects have been shown to impact the conformations and diffusion of proteins, including polymer-like intrinsically disordered proteins. Here we study macromolecular crowding effects in a polymer system consisting of polyethylene glycol (PEG) and Ficoll, which acts as a...

878. COMPUTER SIMULATIONS OF THE FOLDING OF METAMORPHIC PROTEINS B4, SB3 and SB4

Ken Tse Pen Ki

22/06/2026, 16:45

Physics in Medicine and Biology / Physique en médecine et en biologie (DPMB-DPMB)

Oral Competition (Undergraduate Student) / Compétition orale (Étudiant(e) du 1er cycle)

Metamorphic proteins are an unusual class of proteins capable of adopting more than one stable native fold, challenging the classical assumption that a single amino acid sequence encodes a single structure. In this work, we investigate the folding behaviour of three closely related proteins: B4, SB3, and the engineered mutant SB4. Despite differing by only a small number of residues, these...

936. Varieties of the Schelling Model: Foundations for Exploring Positional Choice Models

Marlyn Mwita (University of Waterloo)

22/06/2026, 17:00

Physics in Medicine and Biology / Physique en médecine et en biologie (DPMB-DPMB)

Oral Competition (Graduate Student) / Compétition orale (Étudiant(e) du 2e ou 3e cycle)

Simulating simplified models of social interactions with agent-based models (ABMs) fills a special role in the study of social phenomena, where it is often impossible to design controlled experiments. Schelling’s model of segregation is one of the best-known ABMs, notable for being among the first and simplest to demonstrate how societal outcomes can collectively fail to match individual...

945. Synergistic Effects of H-NS and Crowders on Bacterial Chromosome Organization

Bae-Yeun Ha

22/06/2026, 17:15

Physics in Medicine and Biology / Physique en médecine et en biologie (DPMB-DPMB)

Oral (Non-Student) / Orale (non-étudiant(e))

Cells organize their chromosomes through the coordinated action of chromosome-associated proteins and surrounding molecular crowders. In crowded environments, polymeric chains such as chromosomes can undergo entropically driven condensation. Using a coarse-grained computational model, we examine the physical roles of the cross-linking protein H-NS and crowders in bacterial chromosome...