Speaker
Description
Current clinical magnetic nanomaterials (e.g., Ferumoxytol, Gd-DTPA) exist limitations in narrow imaging window, magnetic susceptibility artifact, and biosafety. Pyrite (FeS2) as a mineral drug with inherent biocompatibility and transition metal dichalcogenide functionality, shows prospect but exhibits weak magnetism due to the low-spin (LS) state of Fe2+ in coprecipitation synthesis. Herein, we reported a strategy using alternating magnetic field (AMF)-coupled coprecipitation to prepare high-spin (HS) FeS2 via spin reconstruction, which achieved LS-to-HS Fe2+ spin transition without exogenous elements. HS-FeS2 exhibited long-range ordering of spin structure mediated by super-exchange interaction, thereby enhancing MRI field gradient response and imaging resolution, not only providing a magnetic candidate with clinical translational potential but also a novel quantum-level strategy to for performance optimization. Leveraging the intrinsic high-spin characteristic of FeS₂, which stems from its unique d-band electronic configuration, the integration of a dedicated MRI enhancement coil promotes the ordered alignment of magnetic moments in the material. This synergistic combination enables high signal-to-noise ratio (SNR) imaging both in vitro and in vivo even under low-field (1.5 T) MRI conditions, effectively overcoming the signal constraints of low-field systems. Ultimately, this optimized imaging platform holds substantial promise for the longitudinal tracking of stem cell differentiation and therapeutic efficacy in preclinical glioma models, thereby laying a foundation for the clinical translation of FeS₂-based magnetic nanomaterials in biomedical imaging.
| Keyword-1 | High-spin pyrite |
|---|---|
| Keyword-2 | Stem cell tracking |
| Keyword-3 | Low-field MRI |