Speaker
Description
Precise intracranial cell delivery is essential for establishing reproducible glioma models, yet conventional manual stereotaxis lacks operational stability and real-time imaging guidance within the Magnetic Resonance Imaging (MRI) environment. This project aims to implement a precise modeling workflow using a dedicated MRI-compatible robotic injection system under 1.5T MRI guidance. The hardware platform integrates a non-metallic robotic manipulator with a specialized injection device, optimized for high-resolution imaging within the confined bore（30cm）. To ensure superior signal-to-noise ratio and animal stability during the procedure, a dedicated small-animal wireless radio-frequency (RF) coil and a gas anesthesia system were incorporated. Under real-time 1.5T MRI monitoring, the system facilitated precise intracranial puncture and cell delivery. Preliminary work has completed three injection trials, with the final subject successfully demonstrating tumor induction as confirmed by follow-up imaging. Next steps include leveraging this robotic platform to explore and evaluate diverse cell-based therapeutic strategies, such as stem cell transplantation and targeted drug delivery, to further assess treatment efficacy in preclinical models.
| Keyword-1 | MRI-guided drug delivery |
|---|---|
| Keyword-2 | Stereotactic robotic system |
| Keyword-3 | MRI-compatible |