Nanoparticles for theranostics with PET and MRI

27 Apr 2023, 09:50
50m
Split, Croatia

Split, Croatia

Mediterranean Institute for Life Sciences (MedILS) Meštrovićevo šetalište 45 HR – 21000 Split Croatia
Positronium in medical applications Positronium in medical imaging

Speaker

Zdenka Kuncic (University of Sydney, Australia)

Description

In nuclear medicine, cancer theranostics refers to the strategy of combining diagnostic imaging with targeted therapy. In this talk, I will discuss how theranostic efficacy may be enhanced by leveraging the unique properties of nanoparticles. Due to their nanoscale size, nanoparticles can penetrate target tissues and tumour cells, and enhance physico-chemical reaction rates. Additionally, nanoscale geometric confinement confers unique physical properties. Superparamagnetic nanoparticles, in particular, offer a unique platform for radiolabelling with PET isotopes, while also enhancing contrast in Magnetic Resonance Imaging (MRI). Additionally, such nanoparticles, when radiolabelled with a therapeutic isotope, can enhance localised damage to tumour cells, thereby improving therapeutic outcomes.

Presentation materials