Conveners
(DPMB) T2-11 Neural Decay and Molecular Clues: Lipid Membranes, Amyloid, and Advanced Imaging Frontiers | Dégénérescence neuronale et indices moléculaires : membranes lipidiques, amyloïde et frontières de l'imagerie avancée (DPMB)
- Dean Chapman (University of Saskatchewan)
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by dementia and memory loss for which no cure or prevention is available. Amyloid toxicity is a result of the non-specific interaction of toxic amyloid oligomers with the plasma membrane. We use biophysical approaches such as atomic force microscopy (AFM), Kelvin probe force
microscopy (KPFM), black lipid membrane (BLM) and...
Introduction: We have used polarized light to image and differentiate protein deposits as biomarkers of different neurodegenerative diseases and their severity; including amyloid deposits in Alzheimer’s disease (AD) and alpha synuclein deposits found in other brain diseases. Here we differentiate, with polarized light, retinal deposits of amyloid beta, associated with AD, from TDP-43...
Invented and developed at the Cross Cancer Institute in Edmonton, Alberta, the MagnetTx Aurora-RT is a made in Canada solution that combines a 6 MV linac producing therapeutic radiation and a biplanar 0.5 T MRI. This treatment platform received FDA clearance and treated its first patients recently. The primary benefit of such a device is to provide 3D MRI with excellent soft tissue contrast...
