Conveners
R2-2 Membrane Biophysics Joint Session Part II (DPMB/DCMMP/BSC) | Session conjointe sur la biophysique des membranes II (DPMB/DPMCM/SBC)
- Maikel Rheinstadter (McMaster University)
- Zoya Leonenko (University of Waterloo)
Biological membranes have a complex composition with hundreds of different lipids and a high protein concentration. The nature of the lateral structure of membranes is hotly debated as experiments reach increasingly higher spatial and temporal resolution and simulations increasingly larger time and length scales. Coarse-grained simulations with the Martini model have enabled a significant jump...
Antimicrobial peptides (AMPs) are broad spectrum antibiotics that utilize electrostatics to selectively attack bacteria. In this talk, I present our discovery of a new class of antibiotic tolerance that Escherichia coli exhibit against human AMPs LL37: the dying bacteria rapidly absorb a large amount of antibiotics helping the remaining cells survive. Like all antibiotics, AMPs need a minimum...
Mitochondrial damage caused by calcium overload is a critical step in stress-induced cell death during stroke and heart attack. This damage is caused by dramatic increase in permeability of the mitochondrial inner membrane – a phenomenon known as Permeability Transition (PT). PT is caused by calcium induced opening of the large pore at the mitochondrial inner membrane. Molecular composition of...
