Speaker
Description
Translocation of a ligand bound spherical cargo which is biochemically associated to a receptor bound substrate through a Burnt bridges ratchet mechanism is fundamentally altered if the cargo is capable of rolling. Directed rolling is an effective method for cargo translocation and arises only for specific ranges in parameter space of this system. In this study we present the dynamical principles of this class of motors and offer a comparison with conventionally studied motors that translocate without rolling. We observe the changes in the dynamics of the cargo as a function of the substrate properties (like stickiness, elasticity, spacing, concentration of receptors and valence) and the chemistry between the cargo and the substrate (force of attraction, rate of receptor cleaving). We evaluate the dynamics of the rolling motor by computing two metrics: the correlation between translational displacement and rotational displacement and the ratio of the total displacement over total distance travelled by the cargo. Finally, we compare the dynamics with a cargo executing pure translational motion on the following basis relevant to motors: speed, detachment probability, persistence and processivity.
