Conveners
T4-7 Biomechanics and Fluid Dynamics (DPMB) | Biomécanique et dynamique des fluides (DPMB)
- Francis Lin (University of Manitoba)
Droplet-based two-phase microfluidics enables high throughput screening analysis by utilizing monodispersed nanoliter-sized droplets as mobilized test tubes. Other advantages of droplet microfluidics over traditional high throughput technology include continuous flow offering continuous processing, minimized cross contamination benefiting from well encapsulated droplets, and rapid mixing due...
The interaction of phospholipid bilayers and monosaccharides constitutes one of the most important and fundamental physical relationships in cellular biology, as both elements are ubiquitous to living cells. The physical effects of sugars in bilayer systems have been studied for decades due their membrane stabilization properties. Sugars have been observed to decrease phase transition...
A key biophysical consideration in cellular biology is the role of motility. That is, can (and how does) a cell move in a preferred direction on its own accord (i.e., swim) for some physiological purpose (e.g., a bias due chemotactic gradient). One means to empirically characterize the result is by quantifying the so-called ‘anomalous diffusion,’ which directly arises from biases, of an...
Caffeine is the most common adjuvant in drug “cocktails”; however, the mechanisms by which the molecule elicits its adjuvant effects remain unknown. The prevalence of membrane mediated drug-lipid interactions for amphiphilic molecules, such as caffeine, is indisputable through membrane partitioning, bioenergetics, and structure. Here, we characterized caffeine’s interactions with cell...
Chemotaxis is a classic mechanism for guiding cell migration and an important topic in both fundamental cell biology and health science. Neutrophil is a widely used model to study eukaryotic cell migration and neutrophil chemotaxis itself can lead to protective or harmful immune actions to the body. While much has been learnt from past research about how neutrophils effectively navigate...
