2017 CAP Congress / Congrès de l'ACP 2017

Session

T3-7 Soft Matter and Molecular Dynamics (DPMB) | Matière molle et dynamique moléculaire (DPMB)

T3-7

30 May 2017, 13:30

Miller Hall 105 (Queen's University)

Conveners

T3-7 Soft Matter and Molecular Dynamics (DPMB) | Matière molle et dynamique moléculaire (DPMB)

• Francis Lin (University of Manitoba)

1785. Polymer translocation: some surprising physics learned from Molecular Dynamics Simulations

Prof. Gary W. Slater (Université d'Ottawa)

30/05/2017, 13:30

Physics in Medicine and Biology / Physique en médecine et en biologie (DPMB-DPMB)

Invited Speaker / Conférencier invité

Polymer translocation is relevant both in vivo and for nanotechnology applications. Not surprisingly, this apparently simple process has been the subject of intense study over the last 20 years or so. For instance, there have been numerous simulation studies examining aspects of both biased and unbiased translocation. In the first part of this talk, I will review our Molecular Dynamics...

1602. Curcumin Protects Lipid Membranes

Richard Alsop (McMaster University)

30/05/2017, 14:00

Physics in Medicine and Biology / Physique en médecine et en biologie (DPMB-DPMB)

CLOSED - Oral (Student, In Competition) / Orale (Étudiant(e), inscrit à la compétition)

Curcumin is the main ingredient in turmeric, a common Indian spice. Curcumin has been used for centuries in traditional medicine, and has been speculated to have anti-inflammatory and anti-oxidant abilities. Modern medicine has also identified a potential anti-Alzheimer’s benefit. However there is no good theory of a common molecular mechanism to describe all these benefits. This has led to...

1766. Non-specific side effects of the steroidal hormones found in oral contraceptives on lipid membranes

Mindy Chapman

30/05/2017, 14:15

Physics in Medicine and Biology / Physique en médecine et en biologie (DPMB-DPMB)

CLOSED - Oral (Student, In Competition) / Orale (Étudiant(e), inscrit à la compétition)

All commercially available pharmaceutical products must undergo rigorous testing to determine their safety and efficacy, however these drugs interact with our bodies on a cellular level is often unknown. Hormonal oral contraceptives are commonly used by women to prevent pregnancy and treat symptoms, such as acne. While the drug mechanism that causes the desired effect – prevention of ovulation...

1840. Role of the variable domain in Drp1 protein assembly: a simulation study

Mr Mehran Bagheri (University of Ottawa)

30/05/2017, 14:30

Physics in Medicine and Biology / Physique en médecine et en biologie (DPMB-DPMB)

CLOSED - Oral (Student, In Competition) / Orale (Étudiant(e), inscrit à la compétition)

Dynamin-related protein 1 (Drp1), a member of the Dynamin superfamily of large GTPases, is the primary mechanoenzyme responsible for mitochondrial fission. It is composed of three main domains: a G domain that weakly binds GTP and hydrolyzes it to GDP, a coiled-coil stalk domain which is involved in self-assembly of Drp1 into into spiral-like aggregates around the circumference of a...

1887. Membrane Cholesterol Protects Against Polymyxin B Nephrotoxicity in Renal Membrane Analogues

Adree Khondker (McMaster University)

30/05/2017, 14:45

Physics in Medicine and Biology / Physique en médecine et en biologie (DPMB-DPMB)

CLOSED - Oral (Student, Not in Competition) / Orale (Étudiant(e), pas dans la compétition)

At the dawn of the post-antibiotic era, the use of “last-line” antibiotics continues to rise due to emergence of antimicrobial resistant bacteria. Until 2015, polymyxin B (PmB), a membrane rupturing antibiotic, was the last without known resistance. Unfortunately, the drug has been clinically hindered from conception due to the occurrence of kidney-related side effects. However, the mechanisms...