2015 CAP Congress / Congrès de l'ACP 2015

Session

T3-9 Molecular Biophysics (DMBP) / Biophysique moléculaire (DPMB)

T3-9

16 Jun 2015, 15:45

University of Alberta

Conveners

T3-9 Molecular Biophysics (DMBP) / Biophysique moléculaire (DPMB)

• Maikel Rheinstadter (McMaster University)

614. Watching proteins fold: capturing the conformational diffusion of single molecules during structural self-assembly

Michael Woodside (University of Alberta)

16/06/2015, 15:45

Medical and Biological Physics / Physique médicale et biologique (DMBP-DPMB)

Invited Speaker / Conférencier invité

The self-assembly of intricate structures by proteins is a complex process involving myriad degrees of freedom. Such “folding” is usually described in terms of a diffusive search over a multi-dimensional energy landscape in conformational space for the lowest-energy structure. The diffusion coefficient, *D*, encodes the rates at which microscopic motions occur during folding and is thus of...

810. Coarse-Grained computer simulations of Alzheimer’s beta-amyloid peptides, using the Mercedes-Benz Hydrogen Bond Potential

Dr Apichart Linhananta (Lakehead University)

16/06/2015, 16:15

Medical and Biological Physics / Physique médicale et biologique (DMBP-DPMB)

Oral (Non-Student) / orale (non-étudiant)

Protein aggregation is a medically relevant phenomenon that can lead to protein-folding diseases such as Alzheimer’s and Prion’s. The aggregation process is largely determined by hydrogen bonds (HB), involving hundreds of peptides, over a period of days or even months. This rules out molecular dynamics (MD) simulations of all-atom protein models in explicit solvents. However, coarse-grained...

609. The Formation of Alzheimer's Plaques in Synthetic Membranes

Jennifer Tang (McMaster University)

16/06/2015, 16:30

Medical and Biological Physics / Physique médicale et biologique (DMBP-DPMB)

Oral (Student, In Competition) / Orale (Étudiant(e), inscrit à la compétition)

Alzheimer’s disease is a type of dementia that affects memory, thinking, and behaviour. One of the hallmarks of the disease is the formation of neurotoxic senile plaques, primarily consisting of amyloid-β peptides. Despite their importance for the pathogenesis of the disease, little is known about the properties of these plaques and the process by which they form. We developed a model...

592. Alzheimer's Disease Amyloid Beta(25-35): An Oligomeric Aggregation Simulation From Monomers to Ordered Filaments

Robert Girardin (Lakehead University)

16/06/2015, 16:45

Medical and Biological Physics / Physique médicale et biologique (DMBP-DPMB)

Oral (Student, In Competition) / Orale (Étudiant(e), inscrit à la compétition)

Amyloid Beta (A$\beta$) plaques have long been correlated with Alzheimer's disease; however, efforts made to link the plaques to pathogenic effects or utilize them for diagnostic purposes have not been very fruitful. Modern investigations point to peptide intermediate structures or their oligomers as likely candidates for the toxic agents, yet much remains unknown about the aggregation life...

787. Kinetics of Chain Motions within the disordered eIF4E-BP2 protein

Zhenfu Zhang (University of Toronto)

16/06/2015, 17:00

Medical and Biological Physics / Physique médicale et biologique (DMBP-DPMB)

Oral (Student, Not in Competition) / Orale (Étudiant(e), pas dans la compétition)

Intrinsically disordered proteins (IDPs) play critical roles in regulatory protein interactions. Cap-dependent translation initiation is regulated by the interaction of eukaryotic initiation factor 4E (eIF4E) with disordered eIF4E binding proteins (4E-BPs) in a phosphorylation dependent manner. Fluorescence correlation and time-resolved anisotropy spectroscopies were used to detect and assess...