Heavy-ion collisions exhibit distinctive phenomenological characteristics relative to pp collisions due to the formation of a considerably larger quark–gluon plasma (QGP), such as an enhancement in the production of X(3872) in PbPb collisions at the LHC. In the seminal work of Satz & Matsui, color screening effects of in-medium heavy-quark potentials were proposed, introducing the concept of quarkonium “melting”. Owing to its unusually large spatial extent and weak binding energy, the X(3872) provides a particularly compelling probe of the QGP, as its internal structure is compatible with a mixed configuration in turn very sensible to the degree of separation of charm systems in the QGP. We employ simple phenomenological arguments to quantify the degree of separation of in-medium heavy-quark systems, bringing together more than a decade of experimental results by the LHC collaborations, ALICE, CMS, LHCb and ATLAS in both hidden-charm sectors, including the X(3872), and hidden-bottom. Through this unified phenomenological study, we discuss how the suppression patterns of quarkonia can provide insight into its evolution to strongly interacting matter.