Conveners
Focus Session: Frontiers of Medical Physics
- Susanna Guatelli
- James Cayley
Focus Session: Frontiers of Medical Physics
- Susanna Guatelli
- James Cayley
This study presents a novel approach to imaging diffuse environments using non-ionising optical tomography combined with inverse Radon reconstruction techniques. We developed and characterised gelatin-based phantom materials with distinct spectral properties, measured using a CloudSpec spectrophotometer across the 350–850 nm range. These materials simulate biological tissues and enable precise...
Aims:
Recently the first first-in-human minibeam radiation therapy (MBRT) treatments with an orthovoltage x-ray unit at Mayo Clinic, Rochester, Minnesota was presented. We present the development of a GEANT4-based radiation transport model to simulate the minibeam radiation field produced using a clinical orthovoltage machine.
Materials and Methods:
The full clinical orthovoltage machine...
Hospital based medical physicists are uniquely positioned at the interface between fundamental research and direct patient benefit. Translating innovations from academia and industry into the hospital setting, however, presents both opportunities and challenges. Translational pathways typically involve the progression of prototypes through feasibility testing, clinical trials, and eventual...
Of the fundamental components of cancer therapy, radiotherapy is by far the one causing the least ecological foot print, compared to surgery and systemic therapy (chemotherapy, immunotherapy). While radiotherapy is mainly a local therapeutic approach, it can help to significantly reduce the requirement for extensive surgery as well as for the need of systemic therapy. From clinical...
Medical Imaging data provides a wealth of information to the health care pathway including diagnosis, understanding disease extent, prognosis, outcome and follow-up. Medical image data can capture anatomical, biological and physiological information through computed tomography, positron emission tomography, magnetic resonance imaging and other approaches. To use this data effectively for an...
Radiation oncology is a cornerstone of modern cancer care, with approximately 40% of patients receiving radiotherapy (RT) during their cancer journey. Central to its success is achieving an optimal therapeutic ratio: maximising tumour control while minimising side effects. Radiation oncology is a highly technical field, where new algorithm and hardware advances drive improvements in patient...
Beam‑shaping assembly (BSA) design using Monte Carlo techniques for accelerator‑based boron neutron capture therapy (BNCT) requires accurate modelling of light‑ion reactions on thin or thick targets, which define the neutron source term for subsequent beam shaping. Geant4 11.1.3, PHITS 3.33, FLUKA 4‑4.0 and MCNP 6.3 have been benchmarked for thick‑target neutron yield and spectra from...
Modelling the early DNA damage induced by radiation is critical for understanding its biological impact. Radiation traversing a cell induces DNA damage through both physical interactions (direct damage) and chemical interactions of radiochemical species (indirect damage) with the DNA strand. Through the combination of DNA geometry models, physics models and chemical tracking, the early DNA...
