30 November 2025 to 5 December 2025
Building 40
Australia/Sydney timezone
AIP Summer Meeting 2025 - University of Wollongong

A modular Geant4 framework for rapid beam shaping assembly design for neutron capture therapy

4 Dec 2025, 14:10
30m
Hope Theatre (Building 40)

Hope Theatre

Building 40

University of Wollongong Northfields Avenue Wollongong NSW 2522
Contributed Oral Frontiers of medical physics Focus Session: Frontiers of Medical Physics

Speaker

Sherryn MacLeod (University of Wollongong)

Description

Accelerator‑based neutron sources (ABNS) are reviving interest in neutron‑capture therapy (NCT) for cancer treatment. However, each facility needs a custom beam‑shaping assembly (BSA) to tailor the neutron spectrum, flux, spatial profile and gamma contamination. We have developed a modular, macro‑driven Geant4 framework that accelerates BSA prototyping and adaptation across facilities.
Our framework allows users to configure beam components - reflector, moderator, filter and collimator - at run‑time from declarative macros. Facility‑specific source terms (energy, current, reaction and phase‑space files from dedicated target simulations) are used to define injected primaries. Built‑in scorers report standard NCT beam‑quality indicators - epithermal/thermal flux, fast‑neutron and contamination at phantom entrance, beam uniformity.
We follow a validation‑then‑adapt workflow: (1) reproduce published BSA geometries that meet IAEA‑style beam criteria to establish baseline fidelity; (2) substitute site‑specific source terms for two systems: ANSTO’s ANTARES 10 MV tandem accelerator and an RFQ linac driven lithium neutron source at Brookhaven National Laboratory; and (3) iteratively adjust geometry under facility constraints (footprint, shielding, available materials) to approach target figures of merit. We will present preliminary designs and sensitivity analyses for both sites, together with a roadmap for experimental characterisation.
By making geometry, physics lists and scoring fully declarative, the framework improves reproducibility, shortens design cycles and provides a common basis for cross‑facility comparison of NCT beam options.

Author

Sherryn MacLeod (University of Wollongong)

Co-authors

Dr Klaudiusz Jakubowski (Australian Nuclear Science and Technology Organisation (ANSTO)) Dr Toshiro Sakabe (Brookhaven National Laboratory) Dr Masahiro Okamura (Brookhaven National Laboratory) Prof. Susanna Guatelli (University of Wollongong) Dr Mitra Safavi-Naeini (Australian Nuclear Science and Technology Organisation (ANSTO))

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