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SUMMARY:SPACE seminar: Mattia Conte - "Polymer physics of 3D genome organi
 zation"
DTSTART:20260414T100000Z
DTEND:20260414T110000Z
DTSTAMP:20260530T150900Z
UID:indico-event-16938@indico.global
DESCRIPTION:\n\n\n\nSpeaker: Mattia Conte (Università di Napoli "Federico
  II")\nAbstract: The human genome is packaged into chromosomes\, long poly
 mer chains confined within the tiny volume of the cell nucleus. Far from b
 eing randomly arranged\, chromosomes fold into complex three-dimensional s
 tructures that are crucial for genome function\, including gene regulation
 . However\, the mechanisms driving this folding remain poorly understood. 
 In this seminar\, I will show how the spatial organization of chromosomes 
 emerges from the statistical physics of self-interacting polymers undergoi
 ng phase transitions\, such as phase separation [1\, 2]. This physical und
 erstanding of genome folding provides a principled predictive framework fo
 r investigating the origins of complex genetic diseases\, including cancer
 \, opening new avenues for applications in biomedicine [3].\nReferences:\n
 \nConte M. et al.\, “Polymer physics indicates chromatin folding variabi
 lity across single cells results from state degeneracy in phase separation
 \,” Nature Communications 11\, 3289 (2020).\nConte M. et al.\, “Loop e
 xtrusion and polymer phase separation can co-exist at the single-molecule 
 level to shape chromatin folding\,” Nature Communications 13\, 4070 (202
 2).\nDekker J.\, ..\, Conte M.\, ..\, Yue F.\, “An integrated view of th
 e structure and function of the human 4D nucleome\,” Nature 649\, 759 (2
 026).\n\n \nZoom link: click here\n\n\n\n\n\nhttps://indico.global/event/
 16938/
LOCATION:Aula 4 (San Marcellino)
URL:https://indico.global/event/16938/
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