Giersch International Conference & SCALE Kick-Off
from
Monday, 2 March 2026 (09:00)
to
Thursday, 5 March 2026 (19:15)
Monday, 2 March 2026
16:00
Welcome: Registration and Coffee
Registration and Coffee
16:00 - 17:00
Room: Lecture Hall
17:00
Welcome: Opening Remarks
Opening Remarks
17:00 - 17:20
Room: Lecture Hall
17:20
Invited Talks
17:20 - 18:50
Room: Lecture Hall
Contributions
17:20
Toward Digital Twins of Development and Disease
-
Dagmar Iber
(
ETH Zürich
)
18:05
Integrative Structural Biology in the era of Artificial Intelligence
-
Max Bonomi
(
Institut Pasteur
)
19:00
Welcome: Reception
Reception
19:00 - 20:30
Room: Faculty Club
Tuesday, 3 March 2026
09:00
Invited Talks
09:00 - 10:30
Room: Lecture Hall
Contributions
09:00
How cellular architecture modulates drug response
-
Stefan Knapp
(
Goethe University
)
09:45
Bayesian metamodeling of early T-cell antigen receptor signaling accounts for its nanoscale activation patterns
-
Barak Raveh
(
The Hebrew University of Jerusalem
)
10:30
Coffee Break
Coffee Break
10:30 - 11:00
Room: Lecture Hall
11:00
Short Talk
11:00 - 11:45
Room: Lecture Hall
Contributions
11:00
From in situ cryoET to digital twins of subcellular segments
-
Sergio Cruz-Leon
(
Max Planck Institute of Biophysics
)
11:20
Control of the condensation of TDP-43 by enzymatic phosphorylation: a perspective from molecular dynamics simulations
-
Lukas Stelzl
(
Johannes Gutenberg University Mainz & IMB
)
11:45
Invited Talks
11:45 - 12:30
Room: Lecture Hall
Contributions
11:45
Computational tools for building models of entire biological systems from light and electron microscopy
-
Stephan Preibisch
(
HHMI Janelia
)
12:30
LUNCH BREAK
LUNCH BREAK
12:30 - 14:00
14:00
Invited Talks
14:00 - 15:30
Room: Lecture Hall
Contributions
14:00
From integrative structural biology to cell biology
-
Andrej Sali
(
UCSF
)
14:45
Biomolecular condensate architecture of an autophagic cargo at molecular resolution in situ
-
Florian Wilfing
(
Max Planck Institute of Biophysics
)
15:30
Coffee Break
Coffee Break
15:30 - 16:00
Room: Lecture Hall
16:00
Short Talk
16:00 - 16:45
Room: Lecture Hall
Contributions
16:00
Multiscale Modeling of Nuclear Membrane Sealing
-
Karen Palacio-Rodriguez
(
Max Planck Institute of Biophysics
)
16:20
Deep-SegCLEM: unified segmentation and matching for correlative light–electron microscopy
-
Soumaya Zaghbani
(
Max Planck Institute of Biophysics
)
16:45
Invited Talks
16:45 - 18:15
Room: Lecture Hall
Contributions
16:45
Towards Digital Twins of Nuclear Pores
-
Martin Beck
(
Max Planck Institute of Biophysics
)
18:15
POSTER SESSION
18:15 - 19:45
Room: Room 0.101 (next to lecture hall)
Wednesday, 4 March 2026
09:00
Invited Talks
09:00 - 09:45
Room: Lecture Hall
Contributions
09:00
Using digital twins to probe the origins of intelligence
-
Samantha Wood
(
Indiana University Bloomington
)
09:45
Short Talk
09:45 - 10:30
Room: Lecture Hall
Contributions
09:45
rRNA expansion segments mediate the oligomerization of inactive animal ribosomes
-
Mara Müller
(
MPI for Brain Research
)
10:05
Area-specific signatures of time-irreversibility in spontaneous neural activity of the mouse brain
-
Jonas Elpelt
(
FIAS
)
10:30
Coffee Break
Coffee Break
10:30 - 11:00
Room: Lecture Hall
11:00
Invited Talks
11:00 - 11:45
Room: Lecture Hall
Contributions
11:00
Towards Digital Twins of the cerebral cortex
-
Sasha van Albada
(
FZ Jülich
)
11:45
Short Talk
11:45 - 12:30
Room: Lecture Hall
Contributions
11:45
In situ structure of a gap junction - stomatin complex.
-
Alexander Gottschalk
(
Goethe University
)
12:05
Insights into the plasma membrane association of Extended Synaptotagmin 3
-
Veronika Thallmair
(
Philipps University Marburg
)
12:30
LUNCH BREAK
LUNCH BREAK
12:30 - 14:00
14:00
Invited Talks
14:00 - 14:45
Room: Lecture Hall
Contributions
14:00
Digital Twins in biology and medicine: bridging experimental models, simulation, and health systems
-
Liesbet Geris
(
University of Liège, KU Leuven, VPH society
)
14:45
Panel discussion: Digital twins - Criteria, Chances and Challenges
14:45 - 15:30
Room: Lecture Hall
Contributions
14:45
Digital Twins – Criteria, Chances and Challenges
15:30
Coffee Break
Coffee Break
15:30 - 16:00
Room: Lecture Hall
16:00
Short Talk
16:00 - 16:45
Room: Lecture Hall
Contributions
16:00
Data Driven Modelling of Limb Bud Growth and Morphogenesis
-
Tim Liebisch
(
EMBL Barcelona
)
16:20
Initiative of Panoramic Digital Life Model Project
-
Liangyi Chen
(
National Biomedical Imaging Center, Peking University
)
16:45
Invited Talks
16:45 - 17:30
Room: Lecture Hall
Contributions
16:45
Building a Virtual Embryo - A Single Cell At a Time.
-
Loic Royer
(
Biohub
)
17:30
Short Talk
17:30 - 18:15
Room: Lecture Hall
Contributions
17:30
Multiscale Investigation of Membrane Remodeling during Selective ER-phagy
-
Ramachandra M. Bhaskara
(
Goethe University
)
17:50
Molecular Digital Twins of Innate Immunity: Insights from Simulations of Human Guanylate-Binding Protein 1
-
Birgit Strodel
(
FZ Jülich
)
18:15
CONFERENCE DINNER
18:15 - 19:15
Thursday, 5 March 2026
09:00
Invited Talks
09:00 - 10:30
Room: Lecture Hall
Contributions
09:00
Teaching AI the Language of RNA: Foundation Models for Regulation and Therapeutic Design
-
Annalisa Marsico
(
Computational Health Center, Helmholtz Munich
)
09:45
Mining Molecular Data: from Single Cell Genomics to Cryo-E
-
Judith Zaugg
(
University of Basel
)
10:30
Coffee Break
Coffee Break
10:30 - 11:00
Room: Lecture Hall
11:00
Short Talk
11:00 - 11:45
Room: Lecture Hall
Contributions
11:00
Nuclear speckle periphery organizes stable intron-retained RNAs into a distinct nuclear retention compartment
-
Josep BIayna
(
Goethe University
)
11:20
From Capability to Confidence: RNA Mass Spectrometry as a Criterion for Digital Twins
-
Stefanie Kaiser
(
Goethe University
)
11:45
Invited Talks
11:45 - 12:30
Room: Lecture Hall
Contributions
11:45
Digital twins for modelling gene expression: applications to association studies and personalized drug recommendation
-
Marcel Schulz
(
Goethe University and Uniklinikum Frankfurt
)
12:30
Lunch Break
Lunch Break
12:30 - 14:00
Room: Lecture Hall
14:00
Short Talk
14:00 - 14:45
Room: Lecture Hall
Contributions
14:00
Molecular mechanism of membrane pore formation triggered by PI(4,5)P2- dependent FGF2 oligomerization
-
Fabio Lolicato
(
Heidelberg University
)
14:20
Learning Biomolecular Ensembles from Experimental Cryo-EM Data
-
Lars Dingeldein
(
FIAS
)
14:45
Invited Talks
14:45 - 15:30
Room: Lecture Hall
Contributions
14:45
Insights into the mitochondrial collective
-
Suliana Manley
(
EPFL - Laboratory of Experimental Biophysics Lausanne
)
15:30
Coffee Break
Coffee Break
15:30 - 16:00
Room: Lecture Hall
16:00
Short Talk
16:00 - 16:45
Room: Lecture Hall
Contributions
16:00
The role of SAM domain in ΔNp63α
-
Srilakshmi Kalathil
(
Goethe University
)
16:20
Parameterization of Molecular Photoswitches for Martini 3 and their Application in Photopharmacology
-
Thilo Duve
(
FIAS
)
16:45
Invited Talks
16:45 - 18:15
Room: Lecture Hall
Contributions
16:45
If Machines Can Learn, Who Needs Scientists?
-
Jeffery Hoch
(
UConn Health
)
17:30
In-cell structural systems modeling
-
Jan Kosinski
(
EMBL
)
18:15
Closing Remarks
18:15 - 19:15
Room: Lecture Hall